【摘要】 目的 探讨选择性5-羟色胺再摄取抑制剂(SSRIs)对重性抑郁症患者社会认知功能的影响。方法 选取重性抑郁症患者60例(研究组),随机分为SSRIs治疗组(n=30)与三环类抗抑郁剂(TCAs)治疗组(n=30);研究组及对照组(n=30)入组后在基线水平、治疗后4周末、12周末进行人际知觉任务(IPT-15)和情绪强度识别任务(EIRT)测验。比较研究组、对照组之间IPT-15与EIRT分值的差异。结果 SSRIs与TCAs均可降低研究组患者的HAMD评分。基线水平时,SSRIs治疗组与TCAs治疗组的IPT-15总分与5个因子分及EIRT总分与6个因子分显著低于对照组。重复测量方差分析显示,时间节点(基线水平、治疗后4周末、12周末)主效应显著,时间节点×组别(SSRIs治疗组与TCAs治疗组)存在交互作用。多变量方差分析显示,4周末SSSRIs治疗组与TCAs治疗组在IPT-15评分和EIRT评分无差异;在治疗后12周末SSRIs治疗组与TCAs治疗组IPT-15评分和EIRT评分差异均有统计学意义,SSRIs治疗组评分明显高于TCAs治疗组。结论 重性抑郁症患者存在社会认知功能障碍,SSRIs可改善其社会认知功能。更多还原

【Abstract】 Objective To investigate the effects of selective serotonin reuptake inhibitors(SSRIs) on social cognition in patients with major depressive disorders(MDD). Methods A total of 60 patients who met the Diagnostic and Statistical Manual of Mental Disorders-5 diagnostic criteria for MDD were allocated to a SSRI treatment group(SSRITG, n=30) and a TC A treatment group(TC ATG, n=30). The emotion intensity recognition task(EIRT) and the interpersonal perception task-15(IPT-15) were measured at baseline and then after 4 and12 weeks of treatment with SSRIs or TCAs. The differences of IPT-15 scores and EIRT scores between research groups and control group were compared. Results Both SSRIs and TCAs decreased the Hamilton Depression Scale(HAMD) scores. At baseline, the total scores and factor scores of the IPT-15 and EIRT were significantly lower in the SSRITG and TCATG than those of the controls. A repeated measures analysis of variance revealed a significant main effect of time period(baseline, 4 weeks, and 12 weeks) and significant interactions for time period x group(SSRITG and TCATG). A multivariate analysis of variance showed no significant differences between the SSRITG and TCATG on IPT-15 scores and EIRT scores at the end of the 4 th week, but there were significant differences between these two groups at the end of the 12 th week. The score of the SSRIs was significantly higher than the TCAs group. Conclusions MDD patients have impairments in social cognitive function, which might be improved by SSRIs.更多还原