【摘要】 目的 探讨血清脑源性神经营养因子(BDNF)和帕金森病抑郁(PDD)的相关性。方法 收集帕金森病(PD)患者56例(其中PDD 23例,非PDD 33例),健康对照56人。测量每组血清BDNF水平。采用病人健康问卷抑郁自评量表(PHQ-9)对PD患者进行抑郁评估,采用H-Y分级对PD患者运动功能进行评估。结果 PD组血清BDNF水平(7.28±1.49)ng/ml明显低于对照组(11.87±2.03)ng/ml,差异有统计学意义(t=2.35, P<0.01)。PDD组血清BDNF水平(4.95±1.33)ng/ml明显低于非PDD组(9.60±1.67)ng/ml,差异有统计学意义(t=3.45,P<0.01)。不同抑郁程度的PDD患者血清BDNF水平比较显示,重度PDD组血清BDNF水平最低。各PDD亚组之间的血清BDNF水平相比较分析有等级相关性(r_s=-0.24,P<0.01)。结论 PD患者血清BDNF水平降低,血清BDNF水平与PD抑郁程度呈负相关,BDNF水平降低可能参与了PDD的病理生理机制。更多还原

【Abstract】 Objective To investigate the correlation between brain-derived neurotrophic factor(BDNF)level in serum and Parkinson disease depression(PDD). Methods A total of 56 patients with Parkinson disease(PD) and 56 healthy controls were recruited. Among the 56 PD patients, there were 23 cases of PDD and33 cases of non-PDD. All patients’ serum BDNF level was examined. Depression was assessed by PHQ-9 for PD patients. All the PD patients were evaluated with Patient Health Questionnaire-9(PHQ-9) for their depression degree, and Hoehn-Yahr grading scale for PD patients’ motor function. Results The serum BDNF level of patients with PD was(7.28 ± 1.49) ng/ml,which was significantly lower than that of the control group(11.87±2.03)ng/ml, and the difference was statistically significant(t=2.35, P<0.01). The serum BDNF level of patients with PDD was(4.95± 1.33) ng/ml, which was lower than that of the patients with non-PDD(9.60 ± 1.67) ng/ml, and the difference was statistically significant(t=3.45, P < 0.01). The comparison of serum BDNF level of PDD patients with different depression levels showed that the serum BDNF level of the severe PDD group was the lowest. The serum BDNF levels of all PDD groups were compared and analyzed with hierarchical correlation(r_s=-0.24,P < 0.01). Conclusions Serum BDNF level decreased in PD patients. Serum BDNF level was negatively correlated with PD depression. The decrease of BDNF level may be involved in the pathophysiology of PDD.更多还原