【摘要】 帕金森病(PD)是一种常见的神经系统变性疾病,其致病因素除细胞功能紊乱及有毒物质作用外,细胞外微环境异常也逐渐受到关注,与此相关的前沿治疗方法主要包括对流增强给药和简单扩散给药,尤其后者的高效性及安全性已在多项研究中得到证实。现以脑间质治疗手段为基础,重点介绍国内学者研发的简单扩散给药在PD治疗领域的全新应用。更多还原

【Abstract】 Parkinson disease(PD) is a common neurodegenerative disease. The abnormity of extracellular microenvironment, as another important pathogenic factor apart from cell dysfunction and toxic action, has been gradually concerned. The leading edge therapy on extracellular dysfunction includes convection-enhanced delivery(CED) and simple diffusion delivery(SDD). The efficiency and safety of SDD has been proved in many advanced studies. In this paper, we summed up studies on cerebral interstitial therapy. On this basis, we highlighted newly-developed application of SDD on PD treatment by domestic scholars.更多还原