【摘要】 目的 探讨精神分裂症衰退患者对愉悦、悲伤、恐怖音乐的情绪反应及脑电α波功率的特点。方法 纳入精神分裂症衰退患者66例,健康对照组30名,采集愉悦、悲伤、恐怖3个音乐片段下的脑电,比较两组被试的主观愉悦度评价及脑电α频段功率。结果 与健康对照组比较,精神分裂症衰退患者对愉悦音乐感觉不到愉悦;对恐怖音乐感觉不到恐怖;对悲伤音乐评价组间差异无统计学意义。在愉悦、恐怖音乐下,精神衰退患者均出现两侧前额叶、两侧颞叶α波功率升高;其左右脑比较,均表现出右侧后颞叶α波功率比左侧更高。结论精神分裂症衰退患者存在音乐诱发情绪障碍:快感缺乏,恐怖感缺乏,其大脑两侧前额叶、颞叶及右侧后颞叶异常α波功率增强,可能是其生物学基础。更多还原

【Abstract】 Objective To explore the emotional response and electroencephalogram a power to happy, sad and horror music in deteriorated schizophrenia patients. Methods A total of 66 deteriorated schizophrenia patients and 30 healthy controls were recruited. The electroencephalogram(EEG) was collected in three music fragments of happy, sad and horror. The subjective happiness score and EEG a power were compared between the two groups. Results Deteriorated schizophrenia patients showed lower pleasure levels to the happy music than healthy controls, and lower fear levels to horror music. There was no statistical difference in the feeling to sad music between the two groups. Deteriorated schizophrenia patients exhibited significantly stronger electroencephalogram a power in bilateral frontal and temporal lobes. The comparison of the left and right brain showed that the α power of the right posterior temporal lobe was higher than that of the left side.Conclusions Deteriorated schizophrenia patients suffer from music induced emotional disorders : anhedonia and lack of horror. The abnormal α power of bilateral frontal lobes, temporal lobes and right posterior temporal lobe of the brain is enhance, which may be the biological basis of it.更多还原