【摘要】 目的探讨老年非小细胞肺癌患者细胞免疫功能变化并分析化疗对细胞免疫功能的影响。方法方便选择2014年1月—2016年12月到该院进行手术治疗的老年非小细胞肺癌患者94例进行临床研究。随机选择同一时期同一年龄段至该院进行体检的健康老年人100名作为对照组。在观察组术前1 d、术后7 d以及术后化疗1个疗程后以及对照组来检时进行CD3+、CD4+、CD8+检查,比较观察组、对照组手术前、术后7 d以及化疗1个疗程后所有参与研究人员的CD3+、CD4+、CD8+、CD4+/CD8+水平。结果观察组术前CD3+、CD4+、CD4+/CD8+水平分别为(56.79±6.08)%、(31.24±9.83)%、(1.54±0.77),明显低于对照组(66.41±7.58)%、(40.39±7.65)%、(2.37±1.42);而CD8水平明显高于对照组;观察组术后CD3+、CD4+、CD4+/CD8+水平分别为(52.33±7.88)%、(28.22±10.66)%、(24.86±8.42),明显低于术前,而CD8水平明与术前无明显变化(P>0.05)。观察组患者化疗后CD3+、CD4+/CD8+水平分别为(47.52±8.52)%、(1.02±0.94),平明显低于术后未化疗时水平(P<0.05),CD4+、CD8+水平虽然也有变化,但与未化疗时差异无统计学意义(P>0.05)。结论老年非小细胞肺癌患者本身细胞免疫功能会呈现明显下降状态,而手术与化疗会进一步损伤患者的细胞免疫。更多还原

【Abstract】 Objective This paper tries to observe the changes of cellular immune function in elderly patients with non-small cell lung cancer, and to analyze the effect of chemotherapy on cellular immune function. Methods 94 cases of elderly patients with non-small cell lung cancer who underwent surgical treatment from December 2014 to January 2016 were convenient selected and studied. A total of 100 healthy old people who were randomly selected from the same age group to the hospital for the same period were randomly selected as the control group. In the observation group preoperative 1 d, postoperative 7 d and postoperative after 1 cycles of chemotherapy and the control group to check for CD3+, CD4+, CD8+ examination, the results of the observation group and the control group were compared before and after surgery and 7 d after 1 cycles of chemotherapy for all researchers involved in the CD3 +, CD4+, CD8+, CD4+/CD8+. Results The levels of CD3 +,CD4+ and CD4+/CD8+ in the observation group were(56.79±6.08)%,(31.24±9.83)% and(1.54±0.77) respectively, which were significantly lower than those in the control group(66.41±7.58%),(40.39±7.65)%,(2.37±1.42), respectively; while the CD8 level was significantly higher than that of the control group; the patients in the observation group CD3+, CD4+, CD4+/CD8+ levels were(52.33±7.88)% and(28.22±10.66)% and(24.86±8.42), significantly lower than the preoperative level of CD8+, but with no obvious change before Ming(P>0.05). The observation group after chemotherapy in patients with CD3+,CD4+/CD8+ levels were(47.52±8.52)% and(1.02±0.94), significantly lower than the level without postoperative chemotherapy level(P<0.05), CD4+, CD8+ level although there were variations, but with no chemotherapy had no significant difference(P >0.05). Conclusion Elderly patients with non-small cell lung cancer cell immune function itself will show a significant decline, while surgery and chemotherapy will further damage the patient’s cellular immunity.更多还原