【摘要】 目的调查浙江中北部农村男性居民的吸烟状况及慢性肾脏病(chronic kidney disease,CKD)患病率,为全民戒烟提高依据。方法问卷调查浙江中北部1627例原住居民进行包括吸烟相关的生活行为,测定研究对象的人体参数及尿液白蛋白和肌酐比值(ACR)、估算肾小球滤过率(e GFR)。结果该人群成人男性吸烟率54. 82%,女性吸烟率1. 76%;经人口年龄性别标化后,该人群ACR患病率为7. 88%(95%CI 6. 57~9. 20),e GFR下降患病率为2. 37%(95%CI 1. 63~3. 11),CKD患病率为9. 21%(95%CI 7. 80~10. 63);吸烟者血清肌酐(Scr)及尿酸(UA)水平明显高于非吸烟者,经比较差异具有统计学意义(P均<0. 001);男性中吸烟者ACR、e GFR下降及CKD患病率分别为6. 36%、2. 72%及8. 48%;与非吸烟者相应指标差异无统计学意义(P均> 0. 05)。结论该人群吸烟者与非吸烟者的慢性肾脏病患病率无明显差异,吸烟者Scr及UA水平明显高于非吸烟者。更多还原

【Abstract】 Objective To understand the effect of smoking on the prevalence of chronic kidney disease( CKD) of rural male residents in the northern and central territories of Zhejiang province so as to inform the national scheme of nationwide quitting tobacco smoking. Methods 1627 former residents of north-central Zhejiang were chosen to respond to aquestionnaire,which included questions on smoking related behavior,the human body parameters and urinary albumin to creatinine ratio( ACR),and measurement of estimated glomerular filtration rate( e GFR). Results The percentage of adult men who smoke tobacco was 54. 82%. The percentage of women was 1. 76%. Given age gender standardized,the prevalence of ACR was 7. 88%( 95% CI 6. 57 to 9. 20); the prevalence of e GFR decreased was 2. 37%( 95% CI 1. 63 ~3. 11); the prevalence of CKD was 9. 21%( 95% CI 7. 80 to 10. 63); the level of creatinine( Scr) and uric acid( UA) of smokers were significantly higher than non-smokers( P < 0. 001); the prevalence of ACR,e GFR decreased and CKD of male smokers were 6. 36%,2. 72% and 8. 48%. Compared to nonsmokers,the difference was not statistically significant( P > 0. 05). Conclusions No significant difference was found in the prevalence of chronic kidney disease between smokers and non-smokers. The Scr and UA levels of smokers were significantly higher than those of non-smokers.更多还原