【摘要】 目的探讨妊娠晚期检测胎儿生长受限孕妇血清同型半胱氨酸(Hcy)水平及其意义。方法研究组为收治的存在胎儿生长受限的孕妇293例;对照组为同期收治的健康单胎妊娠晚期孕妇315例。于妊娠33周检测2组孕妇血清Hcy水平,随访至分娩;对两组的Hcy水平、分娩孕周、新生儿出生体重等进行比较。结果研究组孕妇Hcy水平(10.2±2.9)μmol/L,高于对照组(8.6±2.5)μmol/L,早产发生率(25.3%)高于对照组(11.1%);新生儿出生体重、分娩孕周均低于对照组;2组早产孕妇Hcy水平均高于本组足月产孕妇,早产和足月产孕妇Hcy水平研究组均高于对照组;在研究组3种新生儿体重组中(低、中和巨大儿),低体重组孕妇的Hcy水平最高。结论妊娠晚期孕妇血清Hcy水平升高可影响胎儿的生长发育,需引起高度关注。更多还原

【Abstract】 Objective To study on the significance of detection of serum homocysteine(Hcy)level in pregnant women with late fetal growth.Methods Totally 293 pregnant women with fetal growth restriction were enrolled as study group.The same period of 315 late pregnant women with healthy single pregnancy were selected as control group.The levels of Hcy were measured for two groups at 33 weeks of gestation and all pregnant women were followed up to delivery.The Hcy levels,gestational weeks and birth weight of study group were compared with control group.Results The level of Hcy(μmol/L)of study group was significantly higher than that of control group(10.2±2.9 vs.8.6±2.5),and the rate of premature delivery was higher(25.3% vs.11.1%).The birth weight and gestational weeks were lower in study group.The levels of Hcy of preterm labor for two groups were higher than those in full-term women and higher in study and control group.For preterm and full term women,the hay levels of study were higher than control group.For three groups of newborn birth weight(small,middle and macrosomia),the level of Hcy in small group was highest one.Conclusion The growth and development of the fetus can be affected by higher serum Hcy level for late pregnancy women and should be noticed seriously.更多还原