【摘要】 通过多步反应制备了一种p H响应性磁性介孔二氧化硅纳米复合粒子Fe₃O₄/m Si O₂/聚（丙烯酸异丁酯-co-丙烯酸）（Fe₃O₄/m Si O₂/P（IBA-co-AA））.纳米复合粒子由包覆介孔二氧化硅的Fe₃O₄核和聚（丙烯酸异丁酯-co-丙烯酸）的p H响应性外壳组成.利用红外光谱（FT-IR）、X射线衍射（XRD）、扫描电子显微镜（SEM）、振动样品磁强计（VSM）对其结构、物相和性能进行了表征。以抗癌药物阿霉素（DOX）为模型药物,研究了Fe₃O₄/m Si O₂/P（IBA-co-AA）磁性纳米复合粒子在模拟人体环境中的控释行为.选择SMCC7211肝癌细胞为模型细胞,用MTT法研究载药粒子的细胞毒性,并评价载药纳米粒子在细胞中的抗癌效果.结果表明:Fe₃O₄/m Si O₂/P（IBA-co-AA）可作为包载阿霉素的一种新型纳米材料,载药颗粒具有良好的p H响应性,可以有效释放DOX药物来抑制癌细胞的增殖.更多还原

【Abstract】 A novel type of pH-sensitivities nanoparticles Fe₃O₄/m SiO₂/Poly（isobutyl acrylate-coacrylic acid）（Fe₃O₄/m SiO₂/P（IBA-co-AA））was prepared,which contain a magnetic Fe₃O₄/m SiO₂sphere and a biocompatible copolymer poly（isobutyl acrylate-co-acrylic acid）.The structure and properties of the nanoparticles were characterized by fourier transform infrared spectrometry,X-ray diffraction,scanning electron microscopy,and vibrating sample magnetometry.Then,the drug delivery behaviors of the micelles embedding anti-cancer drug doxorubicin（DOX）in a simulated human body environment were studied.The in vivo antitumor activity was evaluated in liver cancer SMCC7211 cells.MTT assay was used to evaluate cytotoxicity of the magnetic composite nanomaterials.The results showed that the Fe₃O₄/m SiO₂/P（IBA-co-AA）was one of novel and ideal biomaterials as DOX nanocarrier,drug-loading particles can effectively release DOX drugs to inhibit the proliferation of cancer cells.更多还原