【摘要】 建立了电感耦合等离子体质谱法测定格隆溴铵注射液中铬、镍、钼3种残留金属元素的方法。分别在0,500,1 200 W功率下,样品采用硝酸和过氧化氢混合溶液微波消解,在选定的仪器工作条件下测定。铬、镍、钼的质量浓度在5～200 ng/mL范围内具有良好的线性关系,相关系数不小于0.995,方法检出限为0.22～0.49 ng/mL,定量限为1.08～2.46 ng/mL。测定结果的相对标准偏差为1.4%～3.0%(n=11),样品加标回收率为92.88%～111.94%。该方法操作简单、快速,结果准确、可靠,适用于格隆溴铵注射液中铬、镍、钼的测定。更多还原

【Abstract】 A method for the determination of 3 residual metal elements in Cr, Ni, Mo in glycopyrrolate bromide injection by inductively coupled plasma mass spectrometry(ICP–MS) was established. The samples were mixed with nitric acid and hydrogen peroxide at the power of 0, 500, 1 200 W respectively for microwave digestion, and determined at the selected instrument working conditions. The mass concentration of Cr, Ni, Mo had good linearity in the range of 5–200 ng/m L. The correlation coefficients were not less than 0.995, the detection limits were 0.22–0.49 ng/mL, and the quantitative limits were 1.08–2.46 ng/mL. The relative standard deviations of the determination results were from 1.4% to 3.0%(n=11), and the recoveries were 92.88%–111.94%. The method is simple, rapid, accurate and reliable. It is suitable for the determination of Cr, Ni, Mo in the injection of ammonium bromide.更多还原