【摘要】 目的研究帕金森病抑郁(depression in Parkinson’s disease,dPD)的中医证候要素特征。方法将纳入的帕金森病(Parkinson’s disease,PD)患者(254例)按照汉密尔顿抑郁量表(HAMD)分数标准分为抑郁组(HAMD≥8分,135例)和非抑郁组(HAMD<8分,119例),采用帕金森病证候要素量表(PD-PES-13)进行证候要素辨别,比较2组中医证候要素积分和比率的差异,并利用Logistic回归法计算出中医证候要素对dPD发病的危险度。结果抑郁组中阴虚证、内热证、气滞证的比率显著高于非抑郁组(P<0.05),阴虚证、内热证、气滞证及髓减证积分显著高于非抑郁组(P<0.05)。中医证候要素对dPD的危险度显示,dPD的发生与阴虚证(r=0.518,P=0.043)、内热证(r=0.712,P=0.007)和气滞证(r=0.716,P=0.014)呈正相关性,OR值分别为1.679、2.038和2.016。结论 dPD患者的中医证候要素以阴虚、内热、气滞和髓减为主,且前三者均会增加dPD发病的危险度。更多还原

【Abstract】 Objective To study the characteristics of traditional Chinese medicine( TCM)syndrome elements of depression in Parkinson’s disease( d PD). Methods All PD patients( 254 cases)were divided into depression( HAMD≥8,135 cases) and non-depression( HAMD < 8,119 cases) groups according to the scores of Hamilton depression rating scale( HAMD). TCM syndrome elements of two groupswere diagnosed by the pattern element scale of PD( PD-PES-13). The differences in the integral and ratio of TCM syndrome factors in the 2 groups were compared,and the risk degree of TCM syndrome factors on the incidence of dPD was calculated by Logistic regression. Results Compared with the non-depression group,the ratio of yin deficiency syndrome,internal heat syndrome and qi stagnation syndrome in the depression group were significantly higher than those in the non depression group( P<0.05). The score of yin deficiency syndrome, internal heat syndrome, qi stagnation syndrome and medullary reduction were significantly higher than those of non depression group( P< 0.05). The risk degree of TCM syndrome elements to dPD shows that the occurrence of dPD was positively correlated with yin deficiency syndrome( r= 0.518,P = 0. 043),internal heat syndrome( r = 0. 712,P = 0. 007) and qi stagnation syndrome( r= 0.716,P = 0.014),OR value was 1.679,2.038 and 2.016 respectively. Conclusions The major TCM syndrome elements of dPD are yin deficiency,internal heat,qi stagnation and medullary reduction,and the first three could increase the risk of dPD.更多还原