【摘要】 目的探讨重型地中海贫血患儿干细胞移植术后高血压的发生特点及其影响因素。方法调查接受干细胞移植术的重型地中海贫血患儿114例,观察患儿移植术后高血压发生特点,分析高危因素。结果重型地中海贫血患儿干细胞移植术后血压首次升高的时间为移植后0~47d,中位时间10d;在移植后第1个月、第3个月、第6个月,高血压发生率分别为66.7%、31.6%、10.5%。以收缩压升高为主,有8例出现癫痫状态发作,15例轻度头痛症状,6例精神不振;多因素分析显示年龄是其主要影响因素。结论重型地中海贫血患儿干细胞移植术后早期高血压发生较为常见,临床表现多为隐匿性,年龄是移植后高血压发生的高危因素。应加强低龄患儿干细胞移植术后血压监测,及时控制患儿高血压,降低患儿移植术后高血压并发症的风险。更多还原

【Abstract】 Objective To explore the clinical characteristics and risk factors of hypertension after hematopoietic stem cell transplantation for children with thalassemia major.Methods A total of 114 children with thalassemia major receiving hematopoietic stem cell transplantation were studied.Clinical characteristics of hypertension after transplantation were observed and risk factors were analyzed.Results The first onset of high blood pressure occurved between 0 and 47 days after transplantation,with the median being 10 days.The incidence of hypertension was 66.7%,31.6% and 10.5%in the first,third and sixth month respectively.Elevated systolic blood pressure was the manifestation of hypertension.Eight children experienced an epileptic seizure,15 cases had mild headache,and 6 cases were enervated.Age was the main risk factor of hypertension after transplantation.Conclusion High blood pressure is common in early stage after hematopoietic stem cell transplantation for children with thalassemia major.Its clinical manifestation is occult,and age is the risk factor.Blood pressure monitoring should be strengthened in young children after hematopoietic stem cell transplantation to control hypertension,thus to reduce the risk of complications.更多还原