【摘要】 目的研究青年乳腺癌患者术后化疗期抑郁的发生与性激素水平变化的关系。方法采用抑郁自评量表测评150例青年乳腺癌患者术后化疗期间抑郁状态情况,同时采用化学发光法检测患者血清性激素水平,分析抑郁状态与性激素水平的相关性。结果 99例(66%)青年乳腺癌患者术后化疗期存在不同程度的抑郁,抑郁患者的雌二醇水平显著低于无抑郁患者,促卵泡刺激素和促黄体生成素则显著高于无抑郁患者(P<0.05)。化疗期间抑郁评分与血清雌二醇呈负相关(r=-0.72,P<0.05),与促卵泡刺激数呈正相关(r=0.76,P<0.05),与促黄体生成素呈正相关(r=0.79,P<0.05)。结论青年乳腺癌患者术后化疗期抑郁症的发生与化疗导致的血清雌二醇、促卵泡刺激素、促黄体生成素水平的变化密切相关。更多还原

【Abstract】 Objective To study the correlation between depressive state and sex hormone level in postoperative chemotherapy period for young patients with breast cancer.Method Assess depressive state of 150 young patients with breast cancer by Self-rating Depression Scale(SDS).Test their serum sex hormone levels by chemiluminescence.Analyze the correlation between depressive state and sex hormone level.Result 99 cases(66%)of young patients with breast cancer suffer from depression in postoperative chemotherapy period at different degrees.Estradiol concentration for patients with depression is obviously lower than non-depression patients.Level of follicle stimulating hormone and luteinizing hormone for patients with depression is obviously higher than non-depression patients(P<0.05).Score on depression during chemotherapy period has negative correlation with serum estradiol(r=-0.72,P<0.05),positive correlation with follicle stimulating hormone(r=0.76,P<0.05)and positive correlation with luteinizing hormone(r=0.79,P<0.05).Conclusion Depressive state in postoperative chemotherapy period for young patients with breast cancer is closely related to changes of serum estradiol,follicle stimulating hormone and luteinizing hormone caused by chemotherapy.更多还原