10-month-old C57 Bl/6 female mice were divided into control and PM_(2.5) exposure groups. The mice in PM_(2.5) group were exposed to PM_(2.5)( 3 mg·kg~(-1)) for 4 weeks. Mice were sacrificed 24 h,one week,or two weeks after the final exposure,respectively. Histological assessments were detected by H&E stain. The mRNA levels of myocardial hypertrophy related factors( ANP and β-MHC) and matrix metalloproteinases( MMP2 and MMP9) were analysed by real-time PCR. And the protein levels of TGFβ1 and MMP2 were dete...
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