【摘要】 目的:探讨D-二聚体对社区获得性肺炎病情及预后的评估价值。方法:选择某院收治的48例患者,在入院治疗前对D-二聚体进行检测,分析社区获得性肺炎(CAP)患者D-二聚体含量与CURB-65系统评分等级的差异;比较治疗后生存组和死亡组及不同CURB-65系统评分等级患者的D-二聚体含量变化,分析CAP患者的住院时间。结果:根据CURB-65系统评分结果,48例CAP患者中重症患者10例,非重症患者38例;非重症CAP患者D-二聚体浓度为(1558±617)ng/m L,重症CAP患者D-二聚体浓度为(2088±658)ng/m L,2者比较差异有统计学意义(P<0.05)。治疗后生存组D-二聚体浓度为(1610±658)ng/m L,死亡组(2例)D-二聚体浓度为(2765±567)ng/m L,2组比较差异有统计学意义(P<0.05);对不同评分等级的CAP患者住院时间分析结果显示,Score 2患者住院天数(12.7±4.52)d与Score 0患者(7.20±2.02)d及Score 1患者(7.92±2.51)d比较,差异有统计学意义(P<0.05)。结论:D-二聚体能够一定程度上反应CAP患者的病情及预后情况,但是在用于临床前需要进一步的研究和校正。更多还原

【Abstract】 Objective: To research the evaluating value of D-dimer for condition and prognosis of patients with community acquired pneumonia( CAP). Methods: 48 patients in a hospital were included as research subjects. The concentration of plasma D-dimer was measured before treatment,and the difference between the D-dimer concentration and CURB-65 system rating scale was analyzed. After treatment,the difference of the D-dimer concentration between the survival group and the death group was researched,and the hospitalization time of patients with CAP was also analyzed. Results: According to the results of CURB-65 rating system,there were 10 cases of patients with severe CAP and 38 cases with non-severe CAP in all patients. The D-dimer concentration was higher in those with severe CAP( 2088 ng/m L ± 658 ng/m L versus 1558 ng/m L ± 617 ng/m L,P < 0. 05). After the treatment,the non-survivors had higher D-dimer levels( 2765 ng/m L ± 567 ng/m L versus 1610 ng/m L ± 658 ng/m L,P < 0. 05). The hospitalization time of the patients with score2 was longer than those with score 0 and score 1( P < 0. 05). Conclusion: D-dimer can be used to reflect condition and prognosis of patients with CAP,but it needs further study and correction before it is used in clinical practice.更多还原