【摘要】 以羧甲基壳聚糖为原料,聚乙二醇二缩水甘油醚为交联剂,通过反相微悬浮聚合方法,制备出粒径在300⁶00μm的交联羧甲基壳聚糖微球,再以硝酸铈铵为引发剂,使2-丙烯酰胺-2-甲基丙磺酸在微球表面进行接枝聚合,得到含离子交换基团（—COOH、—SO₃H）的可载药栓塞微球。该微球对抗癌药物盐酸阿霉素载药率24h内可达34.6%,较纯羧甲基壳聚糖微球提高了49.8%。该微球在介入疗法治疗肿瘤领域具有很好的应用前景。更多还原

【Abstract】 Surface modified carboxymethyl chitosan embolic microspheres were prepared by crosslinking reaction of carboxymethyl chitosan in a reverse suspension system using poly（ethylene glycol diglycidyl ether）（PEGDE）as the crosslinking agent,followed by graft polymerization of 2-acrylamido-2-methyl propanesulfonic acid on the surface of microspheres.The microspheres showed regular spherical shapes with size distribution ranging from 300μm to 600μm.The ion exchange groups（—COOH,—SO₃ H）were introduced into the microspheres which could load doxorubicin with loading rate as high as 34.6% in 24 hours,raising 46.8% compared to that of pure carboxymethyl chitosan microspheres.The product had bright prospect in the field of interventional treatment of tumor.更多还原