【摘要】 目的:研究沙美特罗联合孟鲁司特钠对小儿支气管哮喘患儿肺功能的保护作用及一氧化氮(NO)、内皮素(ET)、干扰素-γ(IFN-γ)水平的影响。方法:收集2014年4月至2015年4月就诊的120例支气管哮喘患儿,按抽签法分为沙美特罗组40例、联合组40例、孟鲁司特钠组40例。三组均给予支气管解痉剂、吸氧、抗生素、糖皮质激素等常规治疗,实时观察患儿的病情变化,根据情况给予氨茶碱缓释片。沙美特罗组采用沙美特罗替卡送气雾剂治疗。联合组采用孟鲁司特钠联合沙美特罗治疗。孟鲁司特钠组采用孟鲁司特钠治疗。观察和比较三组的治疗疗效、哮鸣音、憋喘、湿啰音的消失时间,FEV1、FEV1/FVC、PEF、NO、ET、IFN-γ水平的变化。结果:治疗后,联合组总有效率显著高于沙美特罗组和孟鲁司特钠组(P<0.05);哮鸣音、憋喘、湿啰音消失时间显著低于沙美特罗组和孟鲁司特钠组(P<0.05);FEV1、FEV1/FVC、PEF显著高于沙美特罗组和孟鲁司特钠组(P<0.05);NO、ET显著低于沙美特罗组和孟鲁司特钠组(P<0.05),IFN-γ显著高于沙美特罗组和孟鲁司特钠组(P<0.05)。结论:两种药物治疗小儿支气管哮喘的疗效优于单用沙美特罗或孟鲁司特钠治疗,可显著改善患儿的肺功能,可能与其有效调节患儿血清NO、ET、IFN-γ水平有关。更多还原

【Abstract】 Objective: To study the effect of salmeterol combined with montelukast sodium on the lung function,Carbon monoxide( NO),Endothelin( ET),interferon-γ( IFN-γ) levels of children with bronchial asthma. Methods: 120 patients of bronchial asthma who were treated from April 2014 to April 2015 in our hospital were selected as research objects. According to draw method,those patients were divided into salmeterol group 40 cases,40 cases of the combined group and montelukast group in 40 cases. three groups were given routine treatment of bronchial antispasmodic,oxygen inhalation,antibiotics and glucocorticoids,aminophylline Sustained-release Tablets was given according to the situation of children. The Salmeterol group was treated with routine treatment combined with salmeterol. while the combined group was treated with Montelukast sodium combined with Salmeterol. montelukast sodium group was treated with montelukast sodium.Then the clinical effect,wheezing,wheezing,wet rales disappeared time,FEV1,FEV1/FVC,PEF,NO,ET,IFN-gamma levels were compared between two groups. Results: The total effective rate of combined group was significantly higher than that of the control group( P <0.05); the disappearance time of wheezing,wheezing and rales were significantly shorter than those of the salmeterol and montelukast sodium group( P <0.05);FEV1,FEV1/FVC,PEF were significantly higher than those of the salmeterol and montelukast sodium group( P<0.05); serum NO,ET levels were significantly lower than those of the salmeterol and montelukast sodium group( P <0.05),IFN-γ was significantly higher than that of the salmeterol and montelukast sodium group( P< 0.05). Conclusion: The combination of two drugs in the treatment of children with bronchial asthma is superior to the treatment of Shah Mette Lo or montelukast sodium,which can significantly improve the lung function of children. It may be related to the effective regulation of serum NO,ET and IFN-gamma levels.更多还原