【摘要】 目的观察黄芪注射液联合阿奇霉素序贯治疗对支原体肺炎儿童机体免疫及炎症相关因子的影响。方法支原体肺炎患儿119例随机分为2组,观察组61例行黄芪注射液联合阿奇霉素序贯治疗,对照组58例行阿奇霉素序贯治疗,连续用药2个疗程。2组患儿均在用药前及治疗结束后2 d内分别检测体液免疫相关指标Ig G、Ig A、Ig M、Ig E,细胞免疫相关指标T淋巴细胞亚群CD₃⁺、CD₄⁺、CD₈⁺、CD₄⁺/CD₈⁺水平及炎症相关因子hs-CRP、IL-2、IL-4、IL-6、IL-8、IL^-10、TNF-α水平。结果 2组Ig M、Ig A、Ig G、Ig E水平均较治疗前明显下降（P <0. 05）,且观察组降幅大于对照组（P <0. 05）。2组CD₃⁺、CD₄⁺、CD₄⁺/CD₈⁺水平均较本组治疗前明显升高（P <0. 05）,CD₈⁺下降（P <0. 05）,且观察组升高或降低的幅度大于对照组（P <0. 05）。治疗后促炎症相关因子hs-CRP、IL-6、IL-8、TNF-α水平均较治疗前下降（P <0. 05）,抗炎症相关因子IL^-10、IL-2升高（P <0. 05）,IL-4水平降低（P <0. 05）,且观察组的变化幅度大于对照组,差异有统计学意义（P <0. 05）。结论黄芪注射液联合阿奇霉素序贯治疗对支原体肺炎能够调整机体免疫及炎症相关因子,提高临床疗效。更多还原

【Abstract】 Objective To observe the effects of Astragalus injection combined with azithromycin sequential therapy on immune function and inflammatory factors in children with mycoplasma pneumonia. Methods A total of 119 children patients with mycoplasma pneumonia were randomly divided into observation group（ n = 61） and control group（ n = 58）. The patients in observation group were treated by Astragalus injection combined with azithromycin sequential therapy,however,the patients in control group were treated by azithromycin sequential therapy only,with two continuous treatment courses for both groups. The levels of CD3,CD4,CD8,CD4/CD8 were detected before treatment and 2 days after treatment in both groups,moreover,the levels of hs-CRP,IL-2,IL-4,IL-6,IL-8,IL^-10 and TNF-α were also detected and compared between two groups.Results After treatment the levels of Ig M,Ig A,Ig G and Ig E were significantly decreased in both groups,as comapred with those before treatment（ P < 0. 05）,and the decrease extent in observation group was more significant than that in control group（ P < 0. 05）. The levels of CD3,CD4 and CD4/CD8 in both groups were significantly higher than those before treatment（ P <0. 05）,while the levels of CD8 were significantly lower than those before treatment（ P < 0. 05）,moreover,the increase extent or decrease extent in observation group was more significant than that in control group（ P < 0. 05）. The levels of proinflammatory cytokines including hs-CRP,IL-6,IL-8,TNF-α and IL-4 were significantly decreased,as compared with those before treatment（ P < 0. 05）,moreover and the change extent in observation group was more significant than that in control group（ P < 0. 05）. Conclusion Astragalus injection combined with azithromycin sequential therapy in treatment of mycoplasma pneumonia can adjust the immune function and inflammation-related factors of patients so as to improve clinical curative effects.更多还原