【摘要】 目的观察黄芪注射液联合阿奇霉素治疗小儿支原体肺炎(MPP)对肺功能及临床症状的影响。方法将119例MPP患儿按照入院的先后顺序随机分成2组进行治疗。对照组58例予阿奇霉素治疗,观察组61例予黄芪注射液联合阿奇霉素治疗,连续用药2周。检测2组患儿治疗前后肺功能改善情况,分别进行潮气呼吸环分析及通气功能检测,观察统计2组患儿退热时间、咳嗽消失时间、干湿啰音消失、X线阴影消失时间及住院时间,比较2组临床疗效。结果观察组临床症状及体征缓解时间、住院时间均短于对照组(P<0.05)。2组患儿治疗后肺通气功能指标用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、最高呼气流速(PEF)、呼气50%时瞬时最大呼气流速(MEP50)、呼气25%时瞬时最大呼气流速(MEP25)、中段呼气流速(MEP25~75)均较治疗前明显改善(P<0.05),但观察组FVC、FEV1、PEF、MEP50、MEP25的改善优于对照组(P<0.05)。治疗后潮气呼吸流速-容量环检测显示,2组VT/k、tPTEF/t-E、%V-PF、25/PF、MTIF/MTEF均较治疗前升高,且观察组高于对照组,差异均有统计学意义(P<0.05)。疗程结束后观察组总有效率100%,对照组91.38%。2组总有效率比较差异有统计学意义(P<0.05)。结论黄芪注射液联合阿奇霉素治疗MPP能有效改善患儿肺功能,较快改善患儿临床症状,缩短住院时间。更多还原

【Abstract】 Objective To observe the effects of Astragalus injection combined with azithromycin on pulmonary function and clinical symptoms in children patients with mycoplasma pneumonia( MPP). Methods A total of 119 children patients with MPP were randomly divided into two groups according to the order of admission. The 58 patients in control group were treated by azithromycin,however,the other 61 patients in observation group were treated by Astragalus injection combined with azithromycin,continuous medication for 2 weeks. The improvement of pulmonary function before and after treatment in both groups was observed. The analysis of the respiratory cycle and the ventilation function were performed. Moreover the antipyretic time,disappearance time of cough,disappearance of dry and wet rales,disappearance of X-ray shadow and hospitalization time as well as clinical curative effects were observed and compared between two grousp. Results The relief time of clinical symptoms and signs,hospital stay in observation group were significantly shorter than those in control group( P < 0. 05). The pulmonary function indexes including FVC,FEV1,PEF,MEP50,MEP25 and MEP25-75 in both groups were significantly improved after treatment( P < 0. 05),but the improvement extent of FVC,FEV1,PEF,MEP50 and MEP25 in observation group was superior to that in control group( P < 0. 05). After treatment the tidal respiratory flow volume ring test showed that the the levels of VT/k,t-PTEF/t E,% V-PF,25/PF,MTIF/MTEF were increased in both groups,moreover,which in observation group were significantly higher than those in control group( P < 0. 05). In addition at the end of treatment,the total effective rate was 100% in the observation group,which was 91. 38% in the control group,there was a significant difference between two groups( P < 0. 05). Conclusion Astragalus injection combined with azithromycin in treatment of MPP in children can effectively improve patient’s lung function,improve clinical symptoms and shorten the hospital stay.更多还原