【摘要】 目的了解华北油田矿区已婚适龄女性高危型人乳头瘤病毒(HPV)感染情况。方法对2015年3月—2017年3月在华北油田矿区所有医院就诊的11 292例女性宫颈脱落细胞行本地区感染率较高的高危HPV基因分型检测。分析不同年龄段感染情况。结果本研究中HPV阳性2000例(17.71%)。<25岁组与>55岁组总HPV感染率高于其他年龄组,但是复合感染率低于其他年龄组(P<0.05)。不同年龄段组5种高危HPV亚型阳性率比较差异无统计学意义(P>0.05)。>25岁组各组中HPV16型与52型感染阳性率高于其他型别(P<0.05)。结论本地区高危型HPV感染主要以16型和52型为主,<25岁组与>55岁组的总HPV感染率较高,重视高危型HPV感染的筛查对于宫颈癌的预防及早诊治具有积极意义。更多还原

【Abstract】 Objective To investigate infection condition of human papillomavirus( HPV) in married females in mining area of Huabei oil field. Methods Cast-off cells from 11292 female cervical tissues admitted during March 2015 to March 2017 were performed high risk HPV genotype detection in the area. Infection conditions of different age groups were analyzed. Results In the study,2000 patients showed positive results of HPV( 17. 71%). In patients less than25-year-old and more than 55-year-old groups,the total rate of HPV infection was significantly higher,but the multiple infection rate was significantly lower than those in other age groups( P < 0. 05). There were no significant differences in positive rates of five high-risk HPV subtypes in all age groups( P > 0. 05). Positive rates of HPV16 and HPV25 were significantly higher than those of other genotypes in patients less than 25-year-old group( P < 0. 05). Conclusion The HPV16 and HPV25 are the main HPV infection subtypes in the area,and the total rate of HPV infection are higher in patients less than 25-year-old and more than 55-year-old groups. It is important to pay attention to screening high risk HPV genotype for prevention,diagnosis and treatment of cervical cancer early.更多还原