【摘要】 采用滴涂法制备三维石墨烯/L-胱氨酸复合物修饰电极（3DGR/L-CysS/GCE）,并用电化学交流阻抗谱（EIS）和扫描电镜（SEM）对电极材料进行表征.以循环伏安法（CV）、恒电位库伦分析法（CPC）、差分脉冲伏安法（DPV）和计时电量法（CC）研究了氯氮平在该修饰电极上的电化学行为.实验结果表明:在pH6.8的Na₂HPO₄-NaH₂PO₄溶液中,氯氮平在3DGR/L-CysS/GCE上是单电子和单质子转移的电化学反应,在2.0×10-5⁵.0×10-4 mol/L浓度内,氧化峰电流与氯氮平的线性关系良好,其检出限（S/N=3）为1.21×10^-6 mol/L.样品测定的回收率为97.5%¹00.8%.更多还原

【Abstract】 The 3 DGR/L-CysS/GCE was prepared by drop-coating method,and characterized by electrochemical impedance spectroscopy（EIS）and scanning electron microscopy（SEM）.The electrochemical behaviors of clozapine at 3 DGR/L-CysS/GCE were studied by cyclic voltammetry（CV）,controlled potential coulometry（CPC）,differential pulse voltammetry（DPV）and chronocoulometry（CC）.The experimental results showed that the reaction of clozapine at 3 DGR/L-CysS/GCE was an electrochemical reaction with one electron and one proton transfer.The peak current and clozapine content showed a good linear relationship in the concentration range of 2.0×10-5⁵.0×10^-4 mol/L,and the detection limit was 1.21×10^-6 mol/L（S/N=3）.3 DGR/L-CysS/GCE was used for the determination of clozapine in tablets,and the recovery was 97.5%¹00.8%.更多还原