【摘要】 目的探讨2型糖尿病患者血脂与尿微量蛋白肌酐比(UACR)的相关性。方法回顾性分析2014年3月至2016年3月秦皇岛市第一医院70例2型糖尿病患者的临床资料,设为糖尿病组,另选取同期健康体检者70例为对照组。比较两组受检者的甘油三脂(TG)、总胆固醇(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)等血脂指标以及尿微量蛋白(UALB)、尿肌酐(CR)、血尿素氮(BUN)、UACR等肾功能指标,采用Spearman相关分析探讨血脂指标与肾功能指标之间的关系。结果糖尿病组患者的TC、TG和LDL-C水平分别为(5.81±1.36)mmol/L、(2.53±0.72)mmol/L、(3.52±0.85)mmol/L,均明显高于对照组的(4.32±1.12)mmol/L、(1.24±0.19)mmol/L、(2.85±0.16)mmol/L,HDL-C水平为(1.15±0.52)mmol/L,明显低于对照组的(1.47±0.22)mmol/L,差异均有统计学意义(P<0.05);糖尿病组患者的UALB、CR、BUN、UACR水平分别为(24.17±12.20)mg/L、(83.34±26.34)μmol/L、(7.12±2.56)mmol/L、(13.46±5.69),均明显高于对照组的(16.32±3.27)mg/L、(72.36±16.35)μmol/L、(4.37±2.10)mmol/L、(5.61±1.65),差异均有统计学意义(P<0.05);TC、TG水平与UACR呈正相关(r=0.079、0.062,P<0.05),HDL-C、LDL-C水平与UACR无显著相关性(r=-0.085、0.087,P>0.05)。结论 2型糖尿病患者伴有一定血脂紊乱及肾功能损伤,且血脂水平中TC、TG与UACR存在相关性。更多还原

【Abstract】 Objective To investigate the correlation between blood lipid and urine albumin-to-creatinine ratio(UACR) in patients with type 2 diabetes mellitus. Methods The clinical data of 70 patients with type 2 diabetes mellitus in the First Hospital of Qinhuangdao City from March 2014 to March 2016 were analyzed retrospectively(diabetic group). At the same time, 70 healthy individuals were selected as control group. The indexes of blood lipids such as triglyceride(TG), total cholesterol(TG), high-density lipoprotein(HDL-C), low density lipoprotein(LDL-C), and renal function indexes such as urinary microprotein(UALB), creatinine(CR), blood urea nitrogen(BUN) and UACR were compared between the two groups. Spearman correlation analysis was used to investigate the relationship between blood lipid indexes and renal function indexes. Results TC, TG and LDL-C levels were(5.81±1.36) mmol/L,(2.53±0.72) mmol/L,(3.52 ± 0.85) mmol/L in the diabetic group, which were significantly higher than(4.32 ± 1.12) mmol/L,(1.24±0.19) mmol/L,(2.85±0.16) mmol/L in the control group, while HDL-C level was(1.15±0.52) mmol/L in the diabetic group, significantly lower than(1.47±0.22) mmol/L in the control group(P<0.05). UALB, CR, BUN, UACR levels were(24.17±12.20) mg/L,(83.34±26.34) μmol/L,(7.12±2.56) mmol/L,(13.46±5.69) in the diabetic group, significantly higher than(16.32±3.27) mg/L,(72.36±16.35) μmol/L,(4.37±2.10) mmol/L,(5.61±1.65) in the control group(P<0.05).TC and TG were positively correlated with UACR(r=0.079, 0.062, P<0.05), and there was no significant correlation between HDL-C, LDL-C and UACR(r=-0.085, 0.087, P>0.05). Conclusion Type 2 diabetes mellitus is associated with certain dyslipidemia and renal dysfunction, and there is a correlation between TC, TG and UACR.更多还原