【摘要】 采用共沉淀法制备了四氧化三铁纳米粒子（Fe₃O₄）,并在Fe₃O₄纳米粒子表面修饰上了氨基。透射电子显微镜（TEM）和傅里叶变换红外光谱（FTIR）显示,纳米粒子分散性良好,粒径约为10 nm,氨基成功修饰在了纳米粒子的表面。以胃癌SGC-7901为目的细胞,依据RGR值考察了Fe₃O₄-NH₂纳米粒子的细胞毒性等级,结果显示,在一定浓度范围内,细胞死亡率与Fe₃O₄-NH₂纳米粒子的浓度成正相关,低于51.2μg/m L时,Fe₃O₄-NH₂纳米粒子的细胞毒性相对较小,Fe₃O₄-NH₂纳米颗粒具有较好的生物相容性。更多还原

【Abstract】 Fe₃O₄ nanoparticles were prepared by the chemical co-precipitation method,and the aminosilane-modified nanoparticles was modified with 3-aminopropyltriethoxysilane（ Fe₃O₄-NH₂）. The aminosilane-modified nanoparticles were analyzed by TEM and FTIR. The results showed that nanoparticles had a good dispersion and the particle size was about 10 nm. The amino groups were successfully modified on the surface of the Fe₃O₄ nanoparticles. The cytotoxicity evaluation of Fe₃O₄-NH₂ nanoparticles on gastric cancer（ SGC-7901） cells were investigated based on RGR values. Results showed that cell mortality was closely relative to the concentration of the nanoparticles in the certain concentration range. The cytotoxicity of nanoparticles was relatively small when the concentration was below 51. 2 μg/m L.Fe₃O₄-NH₂ nanoparticles had good biocompatibility.更多还原