【摘要】 目的探讨老年急性脑梗死患者血清超敏C-反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)及脂蛋白a水平及其临床意义。方法选择80例老年急性脑梗死患者作为研究组,另取80例健康老年人者作为对照组。比较两组血清hs-CRP、Hcy及脂蛋白a的水平,并比较不同严重程度脑梗死患者血清hs-CRP、Hcy及脂蛋白a水平。分析美国国立卫生研究院卒中量表(NIHSS)评分与急性脑梗死患者hs-CRP、Hcy及脂蛋白a水平的相关性。结果研究组患者血清hs-CRP、Hcy、脂蛋白a水平均高于对照组(均P <0. 05)。急性脑梗死患者中,重度组的hs-CRP水平高于轻度组(P <0. 05),血清Hcy和脂蛋白a水平均随着脑梗死严重程度加重而升高(均P <0. 05)。急性脑梗死患者NIHSS评分与hs-CRP、Hcy和脂蛋白a水平呈正相关(均P <0. 05)。结论老年急性脑梗死患者血清hs-CRP、Hcy、脂蛋白a水平升高,三者对急性脑梗死患者的诊断及病情、预后评估具有重要价值。更多还原

【Abstract】 Objective To investigate the serum high-sensitivity C-reactive protein( hs-CRP),homocysteine( Hcy),lipoprotein a levels and their clinical significance in the elderly patients with acute cerebral infarction. Methods Eighty elderly patients with acute cerebral infarction were selected as study group,and another 80 healthy elders as control group. The levels of serum hs-CRP,Hcy and lipoprotein a were compared between the two groups,and the levels of serum hs-CRP,Hcy and lipoprotein a were compared among the patients with acute cerebral infarction of different severities. The correlation of the National Institutes of Health Stroke Scale( NIHSS) score with the level of hs-CRP,Hcy or lipoprotein a of the patients with acute cerebral infarction was analyzed. Results The levels of serum hs-CRP,Hcy and lipoprotein a in the study group were higher than those in the control group( all P < 0. 05). Among the patients with acute cerebral infarction,the level of hs-CRP in the severe group was higher than that in the mild group( P < 0. 05),and the serum Hcy and lipoprotein a levels increased with the increasing severity of cerebral infarction( all P < 0. 05). The NIHSS score correlated with the level of hs-CRP,Hcy or lipoprotein a in the patients with acute cerebral infarction( all P < 0. 05). Conclusion The levels of serum hs-CRP,Hcy and lipoprotein a are elevated in the elderly patients with acute cerebral infarction,which might be of great value for the diagnosis and assessment of severity and prognosis in the patients with acute cerebral infarction.更多还原