【摘要】 目的探讨阿尔茨海默病(AD)患者Ghrelin和炎症因子水平及其相关性。方法选择AD患者(AD组)和健康人群(对照组)各70例。检测并比较两组研究对象外周血的Ghrelin、白细胞介素(IL)-6、IL-1β、肿瘤坏死因子-α(TNF-α)水平,分析AD患者Ghrelin水平与IL-6、IL-1β、TNF-α水平的相关性。结果 AD组Ghrelin水平低于对照组(P<0.05),而IL-6、IL-1β、TNF-α水平高于对照组(均P<0.05)。AD组外周血Ghrelin水平与IL-6、IL-1β、TNF-α水平均呈负相关(均P<0.05)。结论 AD患者外周血的炎症因子水平上调而Ghrelin水平下调,两者密切相关,Ghrelin可能对AD的炎症免疫反应起保护作用。更多还原

【Abstract】 Objective To investigate the Ghrelin and inflammatory factors levels and their correlation in the patients with Alzheimer’s disease( AD). Methods Seventy patients with AD( AD group) and 70 healthy persons( control group) were enrolled. The levels of Ghrelin,interleukin( IL)-6,IL-1β and tumor necrosis factors-α( TNF-α) in the peripheral blood were detected then were compared between the two groups. The correlation of Ghrelin level with IL-6,IL-1β and TNF-α levels were analyzed in the patients with AD. Results Compared to the control group,the Ghrelin level was lower,but the levels of IL-6,IL-1β and TNF-α were higher in the AD group( all P < 0. 05). In the AD group,the Ghrelin level negatively correlated with the levels of IL-6,IL-1β and TNF-α in the peripheral blood( all P < 0. 05). Conclusion The levels of inflammatory factors are up-regulated and the Ghrelin level is down-regulated in the peripheral blood of AD patients,presenting a strong correlation between them. Ghrelin may be protective against inflammatory immune response in AD.更多还原