【摘要】 目的探讨儿童血清25-羟基维生素D₃水平及其与支气管哮喘的关系。方法选择支气管哮喘患儿103例,其中轻度哮喘35例,重度哮喘68例,按随机数字表法分为哮喘Ⅰ组52例和哮喘Ⅱ组51例。并选取健康儿童60例为对照组。两组哮喘患儿均给予规范化治疗,哮喘Ⅰ组加用维生素D治疗。比较对照组与不同严重度哮喘患儿、哮喘Ⅰ组与哮喘Ⅱ组患儿治疗前后血清25-OH-D₃水平,以及两组哮喘患儿的哮喘控制率、症状缓解所需时间、治疗后1年哮喘复发率。结果血清25-OH-D₃水平呈对照组>轻度哮喘患儿>重度哮喘患儿（P<0.05）。治疗后,哮喘Ⅰ组与哮喘Ⅱ组血清25-OH-D₃水平均高于治疗前,且哮喘Ⅰ组血清25-OH-D₃水平高于哮喘Ⅱ组（均P<0.05）;治疗后两组哮喘患儿哮喘控制率均为100.0%,但哮喘Ⅰ组的症状缓解所需时间、哮喘复发率均短于或低于哮喘Ⅱ组（均P<0.05）。结论支气管哮喘患儿血清25-OH-D₃水平降低,且病情越重25-OH-D₃水平越低。辅以维生素D治疗可加速哮喘患儿症状缓解,缩短治疗时间,减少哮喘复发。更多还原

【Abstract】 Objective To explore the relation between serum 25-hydroxyvitamin D₃（ 25-OH-D₃） level and bronchial asthma in children. Methods A total of 103 children with bronchial asthma,including 35 children with mild asthma and 68 children with severe asthma,were divided into asthma group Ⅰ（ n = 52） and asthma group Ⅱ（ n = 51） using the random number table method. And 60 healthy children were selected as control group. All children with bronchial asthma received standardized treatment,and the children of asthma group Ⅰ were also treated with vitamin D. The serum 25-OH-D₃ level before and after treatment were compared among the control group and the children with asthma of different degrees,or between the asthma group Ⅰ and the asthma groupⅡ. The control rate of asthma,the duration for symptoms remission and the recrudescence rate of asthma after 1 year of treatment were compared between the two asthma groups. Results The serum 25-OH-D₃ levels decreased in the order of the control group,the children with mild asthma and the children with severe asthma（ P < 0. 05）. After treatment,the serum 25-OH-D₃ levels decreased in the asthma group Ⅰ and asthma group Ⅱ,and the level of the asthma group Ⅰ was higher than that of the asthma group Ⅱ（ all P < 0. 05）. After treatment,the control rate of asthma was100. 0% in the two asthma groups. The duration for symptoms remission and the recrudescence rate of asthma in the asthma group Ⅰ were less or lower than those in the asthma group Ⅱ（ all P < 0. 05）. Conclusion Serum 25-OH-D₃ level decreases in the children with bronchial asthma,and is less in the children with more severe asthma. Adjunctive therapy of vitamin D can accelerate the symptom remission,decrease the duration for treatment and reduce the recurrence of asthma.更多还原