【摘要】 目的比较阿那曲唑和他莫昔芬对绝经后激素受体阳性转移性乳腺癌[HR(+)MBC]患者的疗效及血清肿瘤相关炎性因子表达水平的影响。方法选取50例HR(+)MBC患者,其中使用芳香化酶抑制剂阿那曲唑治疗者26例(阿那曲唑组),使用传统药物他莫昔芬治疗者24例(他莫昔芬组),比较患者的治疗效果以及治疗前后血清白细胞介素(IL)-1、IL-2、IL-6、IL-8、IL-10和肿瘤坏死因子-α(TNF-α)的表达水平。结果阿那曲唑组的临床疗效优于他莫昔芬组(P<0.05)。治疗后,他莫昔芬组IL-1、IL-8、IL-10和TNF-α水平较治疗前下降(均P<0.05),阿那曲唑组IL-1、IL-8、IL-10、TNF-α水平较治疗前降低(均P<0.05),阿那曲唑组IL-1、IL-2、IL-6、IL-8、IL-10、TNF-α水平均低于他莫昔芬组(均P<0.05)。结论阿那曲唑对HR(+)MBC的疗效优于他莫昔芬;两种药物对肿瘤生长相关炎性因子表达水平的影响存在差异,而这种差异可能与疗效密切相关。更多还原

【Abstract】 Objective To Compare the effects of anadrazole and tamoxifen on the efficacy and expression levels of serum tumor-associated inflammatory factors in patients with hormone receptor-positive metastatic breast cancer[HR( +) MBC]after menopause. Methods Of 50 patients with HR( +) MBC involved,26 patients( anadrazole group) were administered aromatase inhibitor,anadrazole,and 24 patients( tamoxifen group) were administered traditional medicine,tamoxifen. The therapeutic efficacy and the expression levels of serum interleukin( IL)-1,IL-2,IL-6,IL-8,IL-10 and tumor necrosis factor-α( TNF-α) before and after treatment were compared between the two groups.Results The clinical efficacy of the anastrozole group was significantly superior to that of the tamoxifen group( P < 0. 05). After treatment,the levels of IL-1,IL-8,IL-10 and TNF-α decreased in the tamoxifen group compared to the levels before treatment( all P < 0. 05),the levels of IL-1,IL-8,IL-10 and TNF-α decreased in the anadrazole group compared to the levels before treatment( all P < 0. 05),and the levels of IL-1,IL-2,IL-6,IL-8,IL-10 and TNF-α were lower in the anadrazole group than those in the tamoxifen group( all P < 0. 05). Conclusion The efficacy of anastrozole is superior to that of tamoxifen for HR( +) MBC. There is a difference in the effect on the expression levels of tumor-associated inflammatory factors between the two medicines,and that difference might be related to the efficacy closely.更多还原