Objective: To synthesize L-phenylalanine dipeptide derivatives and study their inhibitory effects on tumor cells. Methods: Starting from L-tyrosine or L-phenylalanine,L-phenylalanine dipeptide derivatives were synthesized via acetylation,condensation,nucleophilic substitution and/or alkylation. The cell proliferation inhibiting activities of the derivatives were evaluated by thiazolyl blue tetrazolium bromide( MTT) method. Results: A total of 8 3 a ~ 3 h phenylalanine dipeptide derivatives were synthesized....