【摘要】 目的探析甘露醇联合白蛋白治疗颅脑损伤致颅内压增高的效果。方法选取2016年2月～2018年2月我院收治的90例颅脑损伤致颅内压增高患者为主要研究对象,运用随机数字表法进行分组,45例/组。对照组患者用甘露醇治疗,观察组用甘露醇联合白蛋白治疗,对两组的治疗效果及安全性进行对比分析。结果 (1)两组患者用药前的颅内压对比差异无统计学意义(P> 0.05),经治疗后,观察组患者的颅内压较治疗前均有明显改善,且改善幅度明显优于对照组,两组对比差异有统计学意义(P <0.05),且观察组的药效持续时间明显高于对照组,两组差异有统计学意义(P <0.05);(2)经治疗后,观察组患者的GCS评分明显优于治疗前,且明显优于对照组,两组对比差异有统计学意义(P <0.05);(3)经治疗后,观察组患者的平均血流速度、搏动指数均明显优于对照组,组间对比差异有统计学意义(P <0.05);(4)经治疗后,观察组患者的一次性血尿素氮升高发生率、血钠紊乱发生率及血钾紊乱发生率均明显低于对照组,两组数据对比差异有统计学意义(P <0.05)。结论甘露醇联合白蛋白治疗颅脑损伤致颅内压增高的效果显著,可降低颅内压,延长药效的持续时间,提升患者的生存质量,值得进一步推广应用。更多还原

【Abstract】 Objective To explore the effect of mannitol combined with albumin in treatment of intracranial hypertension caused by brain injury. Methods Ninety patients with intracranial hypertension caused by brain injury who were admitted and treated in our hospital from February 2016 to February 2018 were selected as main research objects.They were divided into two groups according to random number table method,with 45 cases in each group.Patients in the control group were treated with mannitol while patients in the observation group were treated with mannitol combined with albumin.Curative effects and safety of the two groups were compared and analyzed. Results(1)There was no significant difference in intracranial pressure between the two groups before treatment(P > 0.05).After treatment,the intracranial pressure in the observation group was significantly improved compared with that before treatment,and the improvement was significantly better than the control group.The comparative difference between the two groups was statistically significant(P < 0.05).The duration of drug efficacy in the observation group was significantly higher than that in the control group.There was a significant difference between the two groups(P <0.05).(2)After treatment,GCS score of patients in the observation group was significantly better than that before treatment and that of the control group.The comparative difference between the two groups was statistically significant(P<0.05).(3)After treatment,the mean velocity of blood flow and pulsatility index in the observation group were both significantly better than those in the control group.The comparative difference between the two groups was significant(P < 0.05).(4)After treatment,the incidence of one-time increasing blood urea nitrogen,blood sodium disorders and serum potassium disorders of patients in the observation group were all significantly lower than those in the control group.The comparative difference between the two groups was statistically significant(P < 0.05). Conclusion Mannitol combined with albumin in treatment of intracranial hypertension caused by brain injury has a significant effect.It can reduce intracranial pressure,prolong the duration of drug efficacy and improve the quality of life of patients,which is worthy of further promotion and application.更多还原