【摘要】 为了探索一种盐酸曲美他嗪（TMZ）的电化学测定方法,将高纯多壁碳纳米管（MWCNTs）和甘氨酸（Gly）两种修饰材料复合修饰在玻碳电极上,制备MWCNTs/Gly/GCE修饰电极,研究了TMZ在修饰电极上的电化学行为,并成功地建立了一种电化学测定TMZ的新方法。在p H=7. 6的磷酸盐缓冲溶液（PBS 0. 2 mol/L）中,采用循环伏安法（CV）研究了TMZ在MWCNTs/Gly/GCE电极上的电化学行为,发现TMZ在+0. 764 V左右出现一个明显的不可逆氧化峰,表明MWCNTs/Gly/GCE对TMZ的电化学氧化具有良好的催化性能,催化反应历程的研究表明该电极过程为两电子、两质子转移的反应。在最佳条件下,用差分脉冲伏安法（DPV）研究了峰电流与TMZ浓度的关系,发现测定的线性范围为1. 0×10^-5～2. 3×10^-4mol/L,检出限（S/N=3）为5. 71×10^-7mol/L。该方法已成功地应用于药片中TMZ含量的测定。更多还原

【Abstract】 To explore a method for electrochemical determination of trimetazidine hydrochloride（ TMZ）,multi-walled carbon nanotubes（ MWCNTs） and glycine（ Gly） composite were modified on a glassy carbon electrode（ GCE） to make MWCNTs/Gly/GCE modified electrode. A new electrochemical method for the determination of TMZ using MWCNTs/Gly/GCE was established. In0. 2 mol/L phosphate buffer solution（ PBS） of pH = 7. 6,cyclic voltammetry（ CV） was used to study the electrochemical behavior of TMZ at MWCNTs/Gly/GCE electrode. It was found that TMZ showed an obvious irreversible oxidation peak around + 0. 764 V,indicating that MWCNTs/Gly/GCE had a good catalytic performance to the electrochemical oxidation of TMZ. The reaction mechanism study showed that the electrode process was a reaction of two electrons and two protontransfer. Under the optimal conditions,the relationship between peak current and TMZ concentration was studied by differential pulse voltammetry（ DPV）. The linear range of the calibration curve was1. 0×10^-5～ 2. 3×10^-4 mol/L,and the detection limit（ S/N = 3） was 5. 71×10^-7 mol/L. The method was successfully applied to the determination of TMZ in tablets.更多还原