【摘要】 综述了近年来非均相金属催化剂在醇与NH₃还原胺化制备伯胺体系中的应用研究,重点阐述了醇胺化（包括缩合胺化和还原胺化）的反应机理,以及还原胺化制备伯胺所需催化体系的研究进展。醇的脱氢步骤是醇与氨还原胺化制备伯胺反应中的速率控制步骤,不同金属组分由于对NH₃与有机胺的吸附能不同而导致脱氢活性不同。在醇还原胺化制备伯胺的体系中,开发适用于无氢气条件下氢转移胺化的非均相催化剂、选择合适的载体、开发生物质醇合成伯胺的催化技术具有广阔的前景。更多还原

【Abstract】 Application of heterogeneous metal catalysts in the synthesis of primary amines via reductive amination of alcohols and NH₃ is reviewed. Reaction mechanism of alcohol amination（including condensation amination and reductive amination） and catalytic systems used for reductive amination are summarized. Alcohol dehydrogenation is the rate-limiting step in reductive amination of alcohols and NH₃. In addition, metal dehydrogenation activity varies due to their different adsorption capacities for NH₃ and amines. Furthermore,this review gives an overview of primary amine synthesis, including the development of heterogeneous catalysts for reductive amination of alcohols and NH₃ by hydrogen-autotransfer amination without hydrogen,employment of suitable supports and synthesis technology of primary amine compounds from biomass-based alcohols.更多还原