【摘要】 分别以4,9-二烯雄甾-3,17-二酮(4-AD)、9α-羟基-4-雄烯二酮(9α-OH-4-AD)为原料,通过保护反应、亲核取代反应和水解反应,合成了16α-甲基甾体化合物,并利用核磁波谱和红外光谱对其结构进行表征。采用的方法步骤短,收率高,基本避免了构型异构体的产生,副反应少,降低了成本。更多还原

【Abstract】 In this paper, applied new starting materials, some 16α-methyl steroidal compounds were synthesized by protection, nucleophilic substitution and hydrolysis reaction. Their structures were characterized by NMR and IR. The steps of this synthesis method were short, and the yield was high. The process avoided the formation of configuration isomer, and there was almost no side reaction, it greatly improved the yield and reduced the cost.更多还原