【摘要】 肿瘤的转移是恶性肿瘤危及生命的最主要生物学特性。一旦肿瘤出现远处转移,通常就意味着肿瘤进入晚期阶段,单纯靠局部治疗很难治愈,是导致患者死亡的重要原因。研究发现,电压门控钠离子通道(VGSC)不仅在可兴奋细胞中表达,还在许多转移肿瘤细胞中,特别是在某些类型的癌细胞中表达,提示VGSC的表达与癌组织的侵袭和迁移密切相关。本文对近年来VGSC在肿瘤侵袭转移中作用的研究情况进行综述。更多还原

【Abstract】 The metastasis is the most important biological characteristic of malignant tumors. Once distant metastasis occurs in the tumor tissue,this usually means that the tumor has entered the advanced stage,so it is difficult to cure with local treatment alone,which is the main cause of death. It has been found that voltage-gated sodium channels(VGSC)are expressed not only in excitable cells but also in many metastatic cells,particularly in certain types of cancer cells and the expression of VGSC is related to cancer migration,invasion and metastasis in vivo. Therefore,this article reviews recent studies on the VGSC in tumor invasion and metastasis.更多还原