【摘要】 目的旨在探讨分析老年脑卒中患者血清炎症因子与焦虑抑郁程度相关性。方法从2015年1月~2017年6月选取我院收治227例老年脑卒中患者作为研究对象。测定和老年脑卒中患者血清白介素-6(IL-6)、IL-8、IL-10、高敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、可溶性白细胞介素-2受体(SIL-2R)与焦虑抑郁相关性。结果老年脑卒中患者焦虑及抑郁程度越高,其血清IL-6、IL-10、hs-CRP、TNF-α、SIL-2R越高(P<0.05),IL-10越低(P<0.05)。老年脑卒中患者汉密顿焦虑量表(HAMA)评分、汉密顿抑郁量表(HAMD)评分与IL-6、IL-8、hs-CRP和SIL-2R具有显著正相关(P<0.05),与IL-10具有显著负相关(P<0.05)。结论促炎因子能够促进老年脑卒中患者焦虑及抑郁心理,而抗炎因子能够抑制老年脑卒中患者焦虑及抑郁心理更多还原

【Abstract】 Objective To investigate the correlation between serum inflammatory factors and anxiety and depression level in elderly patients with stroke. Methods 227 cases of elderly patients with stroke treated in our hospital were selected as the research objects from January 2015 to June 2017. Their serum interleukin 6(IL-6),IL-8,IL-10,high sensitive C reactive protein(hs-CRP),tumor necrosis factor α(TNF-α),soluble interleukin-2 receptor(SIL-2R)and the Hamilton Anxiety Scale(HAMA)and the Hamilton Depression Scale(HAMD)scores were measured and compared. Results The higher the anxiety and depression in elderly stroke patients were,the higher the serum IL-6,IL-10,hs-CRP,TNF-alpha and SIL-2R were(P<0.05),and the lower the IL-10 was(P<0.05). HAMA and HAMD scores in elderly patients with stroke,had significant positive correlation with serum IL-6,IL-8,hs-CRP and SIL-2R(P<0.05)the HAMD and HAMA scores and IL-10 had significant negative correlation(P<0.05). Conclusion Proinflammatory factor can promote anxiety and depression leval in elderly patients with stroke,while anti inflammation factor can inhibit anxiety and depression in elderly stroke patients更多还原