【摘要】 目的探讨化疗对胃肠肿瘤患者认知功能的影响。方法采用词汇流畅、连线试验A、数字广度、符号编码、Stroop任务5项神经心理测试,对87例胃肠肿瘤患者(胃肠肿瘤组)化疗前、化疗结束后半年的认知功能进行评定,以60例正常健康人(正常组)为对照。结果 (1)化疗前胃肠肿瘤组各认知功能评测与正常组比较差异无统计学意义(P>0.05);(2)化疗后胃肠肿瘤组的连线试验A、数字广度、符号编码、Stroop颜色、Stroop色词干扰成绩较化疗前明显下降(P<0.01),化疗后胃肠肿瘤组的连线试验A、数字广度、符号编码、Stroop颜色、Stroop色词干扰成绩也较正常组差(P<0.05)。结论化疗对胃肠肿瘤患者的认知功能有损害。更多还原

【Abstract】 Objective To explore the effect of chemotherapy on cognitive function in gastrointestinal tumor patients. Methods 87 gastrointestinal tumor patients(gastrointestinal tumor group)were collected. Cognitive functions of all patients were evaluated with 5 neuropsychological tests which include semantic fluency,Trail Making A,digit span,symbol coding,Stroop task before chemotherapy and 6 months after the completion of all chemotherapy.60 normal health subjects(normal group)were collected as controls. Results(1) Before chemotherapy,there were no significant difference in cognitive functions between gastrointestinal tumor group and normal group(P>0.05).(2) After chemotherapy,the performances of Trail Making A,digit span,symbol coding,Stroop color,Stroop color-word interference in gastrointestinal tumor group were decreased(P<0.01). The performances of Trail Making A,digit span,symbol coding,Stroop color,Stroop color-word interference in gastrointestinal tumor group after chemotherapy were also poorer than those in normal group(P<0.05). Conclusion Chemotherapy may impair cognitive function for gastrointestinal tumor patients.更多还原