【摘要】 目的本研究旨在探索ESR1基因多态性与汉族绝经期女性严重抑郁症状的发生是否存在关联。方法从前来上海三所医院妇科门诊就诊的45~55岁围绝经期及绝经后期妇女中纳入432人。对其雌激素α受体基因上的PvuII(rs2234693)和Xba I(rs9340799)多态位点进行基因型检测。同时使用Beck抑郁量表对其抑郁症状进行评估。同时收集研究对象的一般社会人口学及相关妇产科个人史资料。使用Kupperman绝经指数量表及焦虑自评量表对其绝经期症状及焦虑症状进行评估。结果XbaI位点多态性与抑郁症状数量性状存在关联,携带XX基因型的女性较Xx及xx基因型者存在更严重抑郁症状(Add value=1.85,95%CI=0.21~3.48)。而PvuII位点多态性与抑郁症状数量性状无关联。结论 ESR1基因多态性与汉族围绝经期及绝经后期女性严重抑郁症状的发生可能存在关联。更多还原

【Abstract】 Objective To investigate the association between ESR1 gene polymorphisms and depressive symptoms among menopausal women in Chinese Han population. Method Four hundred and thirty two women aged 45-55 were recruited from gynecological clinics of three hospitals in Shanghai who were all in perimenopausal or postmenopausal period. Genotypes of SNP PvuII(rs2234693)and XbaI(rs9340799)on ESR1 gene were tested. They also asked to finish scales of BDI which were used to assess the depressive symptoms,and we also collected demographic data and obstetrics and gynecologyhistory data,KMI and SAS scales were used to assess the severity of anxiety and menopausal symptoms. Result The XbaI polymorphism significantly associated with the BDI,the women with XX genotype is getting more serious depression symptoms than Xx and xx(Add value =1.85,95%CI=0.21~3.48). The PvuII polymorphism was not related to BDI. Conclusion The polymorphisms of ESR1 are associated with severe depressive symptoms in perimemopausal and postmenopausal women in Han population of Chinese.更多还原