【摘要】 目的探讨利培酮对老年脑卒中合并精神疾病患者精神状态和炎性状态的影响。方法选取2012年9月~2015年12月期间我院确诊治疗的老年脑卒中合并精神疾病患者100例,依据治疗方法分为培酮组和对照组,各50例。对照组患者给予常规治疗,培酮组患者在此基础上给予利培酮治疗。采用简易智能精神状态检查量表(MMSE)评估智能情况,采用汉密尔顿焦虑量表(HAMA)评估焦虑状态,采用汉密尔顿抑郁量表(HAMD)评估抑郁状态;采用酶联免疫吸附法(ELISA)检测血清C反应蛋白(CRP)水平,随访6个月,统计分析所有患者干预前后精神状态、CRP水平和干预前、干预后1、3、6个月的焦虑和抑郁状态。结果利培酮组患者治疗有效率明显高于对照组,有显著性差异(P<0.05);培酮组患者干预后血清CRP水平明显低于对照组,有显著性差异(P<0.05);培酮组患者干预后1、3、6个月的HAMA和HAMD得分明显低于对照组,有显著性差异(P<0.05)。结论利培酮可有效改善老年脑卒中合并精神疾病患者的精神状态和炎性状态,提高临床有效率疗效,有利于减少患者焦虑、抑郁等不良情绪的产生。更多还原

【Abstract】 Objective To explore the effect of risperidone on mental status and inflammatory status of senile patients after stroke combined with mental illness. Methods From September 2012 to December 2015,100 elder patients with cerebral apoplexy and mental illness were divided into risperidone group and control group,50 cases in each group. The control group patients were received routine intervention and the risperidone group patients were given risperidone treatment on the basics of the control group. Simple intelligence mental state examination(MMSE),Hamilton anxiety scale(HAMA),Hamilton depression scale(HAMD)were used to assess the status of mental,anxiety and depression. Enzyme-linked immunosorbent(ELISA)was used to detect serum c-reactive protein(CRP)level. Followed up for 6 months and analyzed all results of aboved. Results Treatment efficiency of the risperidone group was significantly higher than that of the control group(P<0.05);CRP level of the risperidone group was significantly lower than that of the control group(P<0.05);1,3,6 months of HAMA and HAMD scores of the risperidone group was significantly lower than that of the control group(P<0.05). Conclusions Risperidone therapy can effectively improve the mental state and inflammatory state of old patients with cerebral apoplexy combined mental illness,improve the clinical curative effect. It is helpful to reduce anxiety and depression of patients.更多还原