【摘要】 目的检测分析1 003例育龄期孕前保健女性抗苗勒管激素(AMH)水平。方法收集东莞市石碣医院2016年1月至2017年4月收纳的1 003例接受孕前保健的女性。将是否发生月经不调、睡眠时间≤6h、体质量指数异常和焦虑抑郁分为2个亚组,采用化学发光法检测血清中的AMH水平。结果与20~<25岁组比,30~<50岁组的AMH明显降低(P<0.05),与25~<30岁组比,35~<50岁组的AMH明显降低(P<0.05),与30~<35岁组比,35~<50岁组的AMH明显降低(P<0.05),与35~<40岁组比,45~<50岁组的AMH明显降低(P<0.05);随着年龄的增高,AMH明显降低(P<0.05),随着年龄的增加,发生月经不调、睡眠时间≤6h、体质量指数异常和焦虑抑郁的例数逐渐增多,各年龄组内,发生月经不调、睡眠时间≤6h、体质量指数异常和焦虑抑郁的AMH明显降低(P<0.05)。结论育龄期女性通过检测外周血AMH可用于评估卵巢功能,随着年龄的增高,月经不调、睡眠时间≤6h、体质量指数异常和焦虑抑郁发生,均可伴随外周血AMH水平降低。更多还原

【Abstract】 Objective To detect the anti-müllerian hormone(AMH)levels in 1 003 women of childbearing age before pregnancy.Methods A total of 1 003 women who received prenatal care from January 2016 to April 2017 in Dongguan Shijie Hospital were collected.According to the occurrence of irregular menstruation,sleep time 6 hor below,BMI and anxiety and depression,the women were divided into 2 subgroups respectively,and the serum AMH were detected by CLIA.Results Compared with 20-<25 years old group,the AMH was significantly lower in 30-<50 years old group(P<0.05).Compared with the 25-<30 years old group,the AMH was significantly lower in 35-<50 years old group(P<0.05).Compared with 30-<35 years old group,the AMH was significantly lower in 35-<50 years old group Compared with the 35-<40 years old group,the AMH was significantly lower in 45-<50 years old group(P<0.05).The AMH was significantly decreased in a way of age dependent manner(P<0.05).With the increase of age,the cases of irregular menstrual bleeding,sleep time 6 hor below,irregular BMI and anxiety and depression had gradually increased.The AMH in irregular menstrual bleeding,sleep time 6 hor below,irregular BMI and anxiety and depression were significantly lower than those of regular menstrual bleeding,sleep time over 6 h,regular BMI and non-anxiety and depression groups(P<0.05).Conclusion AMH can be used to evaluate ovarian function of women in childbearing age.With the increase of age,irregular menstruation,sleep time 6 hor below,irregular BMI and anxiety and depression can be accompanied by the decrease of AMH.更多还原