【摘要】 目的了解新疆生产建设兵团11家临床实验室肝脏酶学项目[丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、γ-谷氨酰转移酶(GGT)和碱性磷酸酶(ALP)]检测结果的可比性,为推动结果互认提供参考依据。方法 2017年第一季度和第二季度组织了2次兵团11家临床实验室肝脏酶学项目的比对活动,每次测定5个批号比对样品。每家实验室指定1套检测系统作为比对系统,按照统一的比对方案进行比对样品测定,采用稳健Z分数法统计结果。评价标准:|Z|≤2表示"满意";2<|Z|<3表示"警戒";|Z|≥3表示"不满意"。结果共4家实验室4个项目所有10个批号比对样品检测结果|Z|≤2。在第一次比对活动中,有5家实验室4个项目5个批号比对样品检测结果|Z|≤2。在第二次比对活动中,有8家实验室4个项目5个批号比对样品检测结果|Z|≤2;有1家实验室5个批号的ALT检测结果均为Z≥3,发生系统正偏移;另有1家实验室5个批号的GGT检测结果均为Z≤-3,发生系统负偏移。结论兵团11家临床实验室应不断加强质量体系标准化建设,才能确保肝脏酶学项目检测结果的一致性。更多还原

【Abstract】 Objective To understand the comparability of the detection results of four items(ALT,AST,GGT,ALP)of liver enzymology in 11 clinical laboratories in Xinjiang Production and Construction Corps(XPCC)and offer reference for improving mutual recognition of the results.Methods Eleven clinical laboratories of XPCC organized the result comparability tests of 4 items of liver enzymology twice in 2017,and the samples with 5 batches were completed in each comparability test.One set of detection system in each laboratory was used as comparability system according to comparability scheme.The detection results were analyzed through Robust Z Score and the evaluation criterion was:|Z|≤2 "satisfied";2<|Z|<3 " warning";|Z|≥3 "not satisfied".Results The detection results of all 10 batch samples in 4 clinical laboratories showed|Z|≤2 in 2 comparability tests.In the first comparability test,the detection results of 5 batch samples for 4 items were|Z|≤2 in 5 laboratories.In the second comparability test,the detection results of 5 batch samples for 4 items were|Z|≤2 in 8 laboratories,but the ALT results of 5 batch samples in 1 laboratory showed positive deviation(Z≥3)and the GGT results of 5 batch samples in the other laboratory showed negative deviation(Z≤-3).Conclusion The 11 clinical laboratories in XPCC should continuously improve quality management system and make sure that the mutual recognition of the detection results of 4 items of liver enzymology is effective.更多还原