【摘要】 p53基因是细胞生长的负性调节因子,正常情况下通过调控细胞的增殖和凋亡发挥抑癌作用,p53突变常导致肿瘤的发生。近年研究发现,长链非编码RNA(lnc RNA)在多种肿瘤的发生发展中起到重要作用。本文将对p53相关的lnc RNA在口腔癌中的研究进展进行论述,旨在为口腔癌患者的治疗提供新策略。更多还原

【Abstract】 p53 gene is a negative regulator of cell growth which can suppress the tumor through the regulation of cell proliferation and apoptosis under normal circumstances. The mutation of p53 often lead to the tumorigenesis. Recently,Long non-coding RNA(lncRNA) was identified as having a function role in the tumorigenesis and development of a variety of tumors. The review aimed to discuss the relationship of LncRNA which associated with p53 and oral cancer, and provide new strategies for patients with oral cancer.更多还原