【摘要】 过氧化物还原酶4(PRDX4)是过氧化物还原酶家族成员,是一种细胞内源性抗氧化剂,可锚定在内质网调节蛋白质氧化折叠,也可分泌到细胞外基质发生抗氧化作用。在女(雌)性生殖系统,氧化应激影响卵巢的功能状态,定位在颗粒细胞及卵母细胞的体细胞型PRDX4(PRDX4s)通过抗氧化应激机制促进卵泡发育成熟、抑制卵母细胞老化,并参与多囊卵巢综合征(PCOS)和卵巢功能减退的病理过程。在睾丸组织内同时表达两种PRDX4亚型,PRDX4s和睾丸特异型PRDX4(PRDX4t)。PRDX4通过抑制内质网应激、清除胞质和细胞外基质活性氧簇(ROS)保护睾丸组织结构与细胞功能,参与调节精子发生和精子形成,抑制生精细胞凋亡。综述PRDX4的结构与功能,及其在调节配子发生中的作用。更多还原

【Abstract】 As a member of the peroxiredoxin family, PRDX4 plays an important role in antioxidation as a endogenous antioxidant. PRDX4 can anchor the endoplasmic reticulum to regulate protein oxidative folding, and secrete into the extracellular matrix as an extracellular antioxidant. In the female reproductive system, oxidative stress affects the physiological state of the ovary. The PRDX4 s expressed in granulosa cells and oocytes can promote follicular maturation through anti-oxidative stress, inhibit oocyte aging, and participate in the pathological process of PCOS and ovarian dysfunction. Two PRDX4 subtypes, PRDX4 s and PRDX4 t, were expressed in testis.PRDX4 inhibits endoplasmic reticulum stress and clears cytoplasm and extracellular matrix ROS, by which PRDX4 protects testicular tissue structure and cell function, participates in regulating spermatogenesis and sperm formation, and inhibits spermatogenic cells apoptosis. This article describes the structure and function of PRDX4 and its role in regulating gametogenesis.更多还原