【摘要】 大骨节病是一种病因与发病机制未明、致残率极高的地方性骨关节病。近年来多项研究成果对其原有的低硒学说、水中有机物中毒学说、毒素中毒学说等假说做出了补充与更新,尤其是在分子生物学领域有了更多突破性进展。本文就现有的大骨节病的病因与发病机制研究成果做一综述。更多还原

【Abstract】 Kashin-Beck disease(KBD)is an endemic and deforming osteoarticular disease.The pathogenesis of KBD is not clear.In recent years,there are many achievements updating the three past etiological hypotheses:low selenium hypotheses,water organic compound poisoning hypothesis and food fungi toxin poisoning hypothesis.In particular,there is a big breakthrough in molecular biology for KBD.This paper summarized the important progress in the etiology and pathogenesis of KBD.更多还原