【摘要】 目的了解甘肃省不同儿童碘营养水平地区孕妇碘营养和甲状腺功能状况,为科学补碘提供依据。方法依据2009年8¹0岁儿童尿碘监测结果选择尿碘中位数≥300μg/L的凉州区、200²99μg/L的临泽县和100¹99μg/L的华亭县为研究地点,并结合本研究8¹0岁儿童尿碘结果,华亭县为碘过量地区、凉州区为碘适宜1地区、临泽县为碘适宜2地区。于2014年6—12月对每个研究点按东、南、西、北、中随机选择一个乡,每个乡随机选择孕妇10名,进行尿碘、甲状腺功能和盐碘检测。采集集中式供水出厂水样2份,在覆盖范围内按东、西、南、北、中各采集末梢水1份;分散式供水每个乡东、南、西、北、中5个方位各采集水样1份进行水碘检测。结果碘过量地区、碘适宜1地区和碘适宜2地区水碘中位数分别为2.32μg/L、0.70μg/L和6.18μg/L;食用盐中位数分别为25.3mg/kg、25.0mg/kg和28.6mg/kg。碘过量地区、碘适宜1地区和碘适宜2地区孕妇尿碘中位数分别为171.0μg/L、174.8μg/L和135.1μg/L（P>0.05）;TSH中位数分别为2.1mIU/L、2.1mIU/L和1.7mIU/L,FT₄均数分别为16.2pmol/L、16.0pmol/L和15.4pmol/L,FT₃均数分别为4.0pmol/L、4.0pmol/L和4.1pmol/L（P均>0.05）。碘过量地区、碘适宜1地区和碘适宜2地区孕妇TgAb阳性率分别为7.8%、3.2%和7.5%,TmAb阳性率分别为3.9%、3.2%和9.4%（P均>0.05）;甲状腺功能异常发生率分别为5.9%、7.3%和5.7%（P>0.05）。结论孕妇碘过量地区和碘适宜1地区碘营养达到了适宜状态,但碘适宜2地区存在碘营养不足;3个地区孕妇甲状腺疾病主要以亚甲减为主;应开展孕妇碘营养和甲状腺功能监测。更多还原

【Abstract】 Objective To investigate the iodine nutrition and thyroid function of pregnant women in Gansu Province,and to provide a scientific basis for iodine supplementation.Methods According to the urine iodine results monitored in 2009,Liangzhou District（median≥300μg/L）,Linze County（median 200-299μg/L）and Huating County（median100-199μg/L）were selected as the surveillance sites.During June and Dec.2014,5 towns were randomly selected from each site according to the different locations,and 10 pregnant women were picked up from each town to detect the urine iodine,thyroid function,and salt iodine.Water samples from water plants and tap water samples were collected to detect the content of iodine.Results The median of water iodine was respectively 2.32 μg/L,0.70 μg/L and 6.18 μg/L in the 3 surveillance sites.The median of salt iodine was respectively 25.3 mg/kg,25.0 mg/kg and28.6 mg/kg.The median of urinary iodine was 171.0μg/L,174.8μg/L and135.1μg/L.The median of TSH was 2.1 mIU/L,2.1 mIU/L and1.7 mIU/L.The mean FT₄ value was 16.2 pmol/L,16.0 pmol/L and 15.4 pmol/L.The mean FT₃ value was 4.0 pmol/L,4.0 pmol/L and 4.1 pmol/L（P>0.05）.The positive rate of TgAb was 7.8%,3.2% and 7.5%,and the positive rate of TmAb was 3.9%,3.2% and 9.4%（P>0.05）.The incidence of thyroid function disorders was 5.9%,7.3% and 5.7%（P>0.05）.Conclusion Iodine nutrition level was appropriate for pregnant women in the 3 areas,but still some women were iodine deficient.Subclinical hypothyroidism and low-FT4 syndrome developed in some pregnant women.Iodine nutrition and thyroid function of pregnant women should be monitored.更多还原