【摘要】 目的 :分析闭环管理方法在分子靶向药物曲妥珠单抗(赫赛汀)用药安全管理中的应用效果。方法 :运用闭环管理模式和智能信息化管理在赫赛汀医嘱开单系统设置、用药自动计算用量、用药单次单剂量计费、赠药模式规范化、药物集中配置、规范药物使用核对、输液环节安全管理等方面改进。结果:闭环管理后开具医嘱耗时、核对药物耗时增加(P<0.001),首次发药耗时、配置药物耗时缩短(P<0.001),输注药物耗时差异无统计学意义(P>0.05),赫赛汀药物相关不良事件发生率降低(P<0.001)。结论 :赫赛汀用药安全闭环管理流程实现了以患者为中心的服务模式,可明显提升用药的安全性,减少发生错误的环节,提高医护工作效率。更多还原

【Abstract】 Objective: To explore the application effect of closed-loop safety management of molecular targeted drug trastuzumab(herceptin). Methods: Using closed-loop concept and intelligent information management system, several steps were improved, including setting herceptin orders sheet, automatic calculation of dosage, a single-dose billing, medication donation standardization, centralized configuration, standardizing drug use check, and infusion process safety management. Results: The time of prescriptions and the time on the drug check increased(P<0.001). The times of first drug delivery and drug allocation were shortened(P<0.001). There was no significant difference in infusion time between the two groups(P>0.05). Adverse events of herceptin decreased significantly(P<0.001). Conclusion: The closed-loop safety management process of herceptin was a kind of the patient centered service, which could obviously improve the drug use safety, reduce the process errors and improve the efficiency of medical care.更多还原