目的:探讨心脏死亡供体器官捐献(donation after cardiac death,DCD)来源角膜植片术后排斥反应与角膜内皮细胞的相关性。方法:用角膜内皮显微镜对心脏死亡供体来源角膜植片行穿透性角膜移植术后发生排斥反应的28例28眼角膜植片分别于术后<1、2~3、4~6、7~12mo行角膜内皮镜检查。结果:28例患者术后<1、2~3、4~6、7~12mo的角膜内皮细胞变异系数分别为38.23%、49.56%、57.18%、65.04%;角膜内皮细胞密度分别为2071.15±311.47、1771.33±348.18、1626.59±353.92、1553.14±307.31个/mm2;角膜内皮细胞变异系数与排斥反应呈正相关关系(r=0.95,P<0.05);术后角膜内皮细胞密度与排斥反应呈负相关关系(r=-0.93,P<0.05)。结论:DCD穿透性角膜移植术后发生排斥反应时有角膜内皮细胞变异系数逐步增高,角膜内皮细胞密度逐步降低的趋势;角膜内皮细胞变异系数、角膜内皮细胞密度可作为早期检测术后排斥反应的指标。
【英文摘要】
AIM: To study the relativity between reject reaction from donation after cardiac death( DCD) and corneal endothelial cell source of corneal graft after penetrating keratoplasty.METHODS: Totally 28 cases of corneal graft rejection after penetrating keratoplasty with cardiac death donor cornea were analyzed using corneal endothelial microscope at less than 1 mo,2-3 mo,4-6 mo,7-12 mo after operation. RESULTS: Coefficient variation of corneal endothelial cell of the 28 cases at less than 1 mo,2-3 mo,4-6 mo and7...
【基金】
昆明市科技局计划重点项目(No.2014-04-A-S-02-2091)~~
【更新日期】
2018-01-18
【分类号】
R779.65
【正文快照】
650000,Yunnan Province,China.641106144@qq.comMETHODS:Totally 28 cases of corneal graft rejectionafter penetrating keratoplasty w ith cardiac death donorcornea w ere analyzed using corneal endothelialm icroscope at less than 1m o,2-3m o,4-6m o,7-12m oaft