Some amphiphilic copolymers in water can undergo a reversible sol-gel transition upon heating. If the transition temperature lies between room temperature and body temperature, the aqueous system can be readily mixed with drugs or cells at room temperature, and the mixture is injectable; the injected formulation is physically gelled at body temperature, and the gelation is free of any chemical crosslinking. This affords an amazing biomaterial type, yet many questions are open in light of fundamental researc...
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