【摘要】 目的系统评价趋化因子受体7(C-X-C chemokine receptor type 7,CXCR7)在肿瘤患者预后判断中的价值。方法计算机系统检索Pub Med、Web of Science、Embase、CBM、VIP、CNKI和Wan Fang数据库收录的所有肿瘤中CXCR7表达与患者临床预后关系的文献,检索时间从建库至2017年5月30日。由两位研究者按照纳入和排除标准筛选文献并评价纳入研究质量后,应用RevMan5.1软件进行数据分析。采用风险比(HR)和95%可信区间(CI)评估CXCR7与总体生存期(OS)和无瘤生存期(DFS)的累积效应。结果最终共纳入19项研究,Meta分析结果显示:CXCR7高表达比CXCR7低表达或不表达的肿瘤患者总体生存期(HR=1.52,95%CI=1.31~1.77,P<0.01)和无瘤生存期(HR=6.80,95%CI=2.25~20.56,P=0.001)低。在胆囊癌、肝癌和胰腺癌等肿瘤患者中,CXCR7高表达均较低表达或不表达的患者总体生存期低,而CXCR7高表达的食管癌患者并未显示出比低表达的患者有更大的死亡风险(HR=1.39,95%CI:0.82~2.36),差异无统计学意义(P=0.216)。结论 CXCR7的表达对消化道肿瘤患者的总体生存期和无瘤生存期具有预测价值,可作为判断消化道肿瘤患者预后的指标。更多还原

【Abstract】 objective To assess the value of C-X-C chemokine receptor type 7(CXCR7) expression in the prognosis of digestive system tumor. Methods Pub Med, Web of Science, Embase, CBM, VIP, CNKI and Wanfang Data were searched for collecting retrospective cohort studies on the correlation between CXCR7 expression and clinical prognosis of cancer patients, and relevant articles were also retrieved from inception to May 30, 2017. According to the inclusion and exclusion criteria, two researchers screened literature and evaluated the quality of the included studies independently. Meta-analysis were performed by RevMan 5.3.1 software. The pooled effect was calculated and the correlations between CXCR7 and overall survival(OS), disease-free survival(DFS) were evaluated by Meta-analysis with hazard ratio(HR) and 95% confidence interval(CI). Results A total of 19 studies were included. Meta-analyses showed that OS and DFS of patients with CXCR7 over-expression were significantly shorter than those with low or negative expression. The HR for OS and DFS was 1.52 and 6.80, the 95%CI were 1.31~1.77 and 2.2~20.56 respectively, and the differences were statistically significant(P<0.01, P=0.001). CXCR7 expression were shorter than those with low or negative expression of CXCR7 in gallbladder cancer, hepatocellular cancer and pancreatic cancer patients. But CXCR7 over-expression has no more risks for those with CXCR7 low or negative expression in esophageal cancer, the difference was no statistically significant(P=0.216). Conclusion The expression of CXCR7 has predictive value for the overall survival and disease-free survival time of digestive system tumor, and CXCR7 can be recommended as a useful survival biomarker in clinical practice.更多还原