节点文献

聚乙烯亚胺修饰BaGdF5纳米粒子的制备及CT/MR双模成像性能

Synthesis of PEI-conjugated BaGdF5 Nanoparticle for in vivo Dual-modal MR and CT Imaging

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 刘建华施展李波张天琪崔凤至袁庆海

【Author】 LIU Jianhua;SHI Zhan;LI Bo;ZHANG Tianqi;CUI Fengzhi;YUAN Qinghai;State Key Laboratory of Inorganic Synthesis and Preparative Chemistry,College of Chemistry,Jilin University;The Second Hospital of Jilin University;

【通讯作者】 袁庆海;

【机构】 吉林大学无机合成与制备化学国家重点实验室化学学院吉林大学第二医院

【摘要】 通过微波辅助的溶剂热法制备了聚乙烯亚胺修饰BaGdF5纳米粒子,并对其进行了表征、毒性评估、计算机X射线断层扫描(CT)成像及磁共振(MR)成像分析.透射电子显微镜(TEM)观测结果表明,该纳米粒子呈球形,表面光滑,分布均匀,粒径约30 nm.MTT结果表明,该纳米粒子具有较低的细胞毒性;小鼠各器官的组织病理学结果表明,该纳米粒子具有较低的体内毒性;体外成像结果表明,该纳米粒子具有较好的CT成像及T1加权的MR成像能力;小鼠体内成像结果表明,该纳米粒子具有应用于肝脏双模态成像的潜力.

【Abstract】 PEI-conjugated BaGdF5 nanoparticles were synthesized via a one-pot facile but efficient microwaveassisted polyol process. Transmission electron microscopy( TEM),X-ray diffraction( XRD),FTIR spectroscopy,cytotoxicity test,CT imaging and MR imaging were used to characterize these well-prepared nanoparticles.TEM images indicated that these nanoparticles held an average diameter of 30 nm with uniform spherical character and relatively smooth surface. MTT result indicated these nanoparticles showed a very low cytotoxicity. Both in vitro and in vivo imaging results demonstrated that these nanoparticles exhibited excellent dual-modal MR and CT imaging capabilities,indicating their potential applications in further clinical areas.

【关键词】 CT成像MR成像纳米粒子造影剂
【Key words】 CT imagingMR imagingNanoparticlesContrast agent
【基金】 国家自然科学基金(批准号:81571737);吉林省自然科学基金(批准号:20180101119JC);吉林省卫计委青年基金(批准号:2017Q012)资助~~
  • 【文献出处】 高等学校化学学报 ,Chemical Journal of Chinese Universities , 编辑部邮箱 ,2018年09期
  • 【分类号】TB383.1;TQ421.7
  • 【被引频次】4
  • 【下载频次】124
节点文献中: 

本文链接的文献网络图示:

本文的引文网络