【摘要】 在三相模型的基础上,结合Langmuir等温吸附方程和药物释放方程,建立了弱聚电解质水凝胶溶胀释药的数学模型;运用有限元方法,研究了药物在弱聚电解质水凝胶内均匀分布时凝胶体系的材料参数对溶胀及释药性能的影响;分析了水凝胶在不同阶段的释药机理;比较了药物在载药基体内的均匀分布和不均匀分布模式对凝胶释药性能的影响,当药物在载药基体内正弦分布时呈现零级释药动力学特点;对比分析了模拟结果与实验结果,验证了弱聚电解质水凝胶溶胀释药模型的准确性.更多还原

【Abstract】 Based on the three-phase model,a mathematical model of swelling and drug release for weak polyelectrolyte hydrogels was established by combination of Langmuir isothermal adsorption equation and drug release equation; the finite element method was adopted to investigate the influence of the material parameters on swelling and drug release in the case of drugs were distributed within the weak polyelectrolyte hydrogels homogeneously; the mechanism of drugs released from weak polyelectrolyte hydrogels in different moments was analyzed as well; then the impacts of drug distribution conditions within the hydrogels which consist of homogeneous distribution and inhomogeneous distribution on swelling and drug release were compared comprehensively,and it has been found that drug release process is consistent with zero order release kinetics when drugs presented the sine distribution in the hydrogels; finally,the simulated results were comparatively compared with Beebe’s experimental results to validate the accuracy of this simulation.更多还原