Objective To investigate the correlation between albumin to globulin ratio( AGR) with disease activity in systemic lupus erythematosus( SLE). Methods A total of 301 patients with SLE were selected. The clinical data and lab indexes were retrospectively analyzed. Binary logistic regression analysis and ROC curve of serum AGR level were used to investigate the correlation of AGR with disease activity. Results According to SLEDAI,inactive group( n = 65,SLEDAI = 0-9) and active group( n = 236,SLEDAI≥10) were al...