目的探讨限盐饮食对一级高血压合并2型糖尿病患者心血管风险(血压、尿白蛋白、血浆肾素及醛固酮)的影响。方法入选152例未使用药物治疗的一级原发性高血压合并2型糖尿病患者,分为限盐饮食组及常规饮食组,各76例。建议限盐饮食组患者限盐(5 g/d)。入组前检测诊室血压、动态血压,24 h尿钠、24 h尿白蛋白排泄率,肝肾功能、空腹血糖、餐后2 h血糖、糖化血红蛋白、血电解质、血浆肾素活性及醛固酮。12周观察期结束时复查上述指标,并比较上述指标组内及组间差异有无统计学意义。另外,通过多元线性回归分析筛选出影响24 h尿白蛋白排泄率的独立危险因子。结果 76例限盐饮食组患者限盐饮食12周后,尿钠由(182±13) mmo L/24 h降至(110±16) mmo L/24 h;尿白蛋白排泄率由(87±7) mg/24 h降至(46±5)mg/24 h;诊室血压:收缩压由(147±9) mm Hg降至(139±7) mm Hg,舒张压由(94±6) mm Hg降至(90±7)mm Hg,平均动脉压由(111±3) mm Hg降至(106±6) mm Hg;动态血压:24 h平均收缩压血压由(142±7) mm Hg降至(...
【英文摘要】
Objective To investigate the effect of modest salt reduction on cardiovascular risk( blood pressure,urinary albumin,renin and aldosterone) in patients with mild hypertensives and type 2 diabetes mellitus( T2DM). Methods A total of 152 patients with mild hypertensives and T2DM without drug treatment were recruited. They were assigned into reduced salt diet and usual diet groups. Participants in reduced salt diet group were given with detailed dietary advice to reduce salt intake to 5 g/d. Measurements were p...